Results 211 to 220 of about 709,386 (365)
Optimizing Lymphocyte Detection in Breast Cancer Whole Slide Imaging through Data-Centric Strategies [PDF]
arXivEfficient and precise quantification of lymphocytes in histopathology slides is imperative for the characterization of the tumor microenvironment and immunotherapy response insights. We developed a data-centric optimization pipeline that attain great lymphocyte detection performance using an off-the-shelf YOLOv5 model, without any architectural ...
arxiv
Interdisciplinary Medicine, EarlyView.Left: The disruption of the balance between carcinogenic bacteria and probiotics mediated by antibiotics, protein, and glucose intake. Middle: The gut microbiota‐derived amino acids, primarily through tryptophan, tyrosine, arginine, and branched‐chain amino acid pathways, regulate glioma development via mechanisms such as AHR activation, metabolic ...
Qianquan Ma +10 more
wiley +1 more source
Engineered strategies for the allergic disease therapy
Interdisciplinary Medicine, EarlyView.Allergic diseases exist widely across the globe and now there are very limited therapeutics for the treatment of these diseases. In this review, we summarize the recent advances in engineering strategies including nanoemulsion and hydrogel to improve the therapeutic efficacy of allergen‐specific immunotherapy with decreased side effects and long‐term ...
Yun Tian +4 more
wiley +1 more source
Frontiers in Cellular and Infection MicrobiologyIntroductionMicrobial dysbiosis links to mucosal immune dysregulation, but the specific bacterial contributions to oral mucosal inflammation remain unclear. Escherichia coli (E.
Jia Liu +18 more
doaj +1 more source
Biotin Deficiency Induces Th1- and Th17-Mediated Proinflammatory Responses in Human CD4+ T Lymphocytes via Activation of the mTOR Signaling Pathway [PDF]
, 2018 Asif Elahi +6 more
openalex +1 more source
Comorbidities of Primary Scarring Alopecias: A Retrospective Multi‐Site Cross‐Sectional Study
JEADV Clinical Practice, EarlyView.ABSTRACT Background To date, limited research has compared the systemic comorbidities of primary scarring alopecia types. Such research may provide insight into shared disease mechanisms, elucidate novel pathways for therapeutics, and identify those most at risk of comorbidities.
Arielle Carolina Mora Hurtado +7 more
wiley +1 more source
IL-1 regulates the IL-23 response to wheat gliadin, the etiologic agent of Celiac Disease [PDF]
, 2008 Celiac disease (CD) is an autoimmune disease prevalent in ~1% of the general population. CD is unique because both the major genetic (Human Leukocyte Antigen-DQ2/DQ8 alleles) and etiologic factors (dietary glutens) for susceptibility are known.
Alessio Fasano +2 more
core +1 more source
International Journal of Laboratory Hematology, Volume 45, Issue 1, Page 53-63, February 2023., 2023 Abstract Introduction Paediatric AML patients with hyperleukocytosis have a poor prognosis and higher early mortality. Therefore, more studies are needed to explore relevant prognostic indicators and develop effective prevention strategies for this type of childhood AML. Methods All original data were obtained from the TARGET database.
Nan Mei +6 more
wiley +1 more source
Movement Disorders, EarlyView.Abstract Background Parkinson's disease (PD) is the most common neurodegenerative movement disorder and one of the world's fastest‐growing neurological diseases. Although the exact causes of PD are unknown, mitochondrial dysfunction and inflammation may have significant roles in disease progression.
Fatima Afaar +6 more
wiley +1 more source