Smart Medicine, Volume 4, Issue 2, June 2025.This study reveals that polyamine metabolism significantly impacts thyroid carcinoma progression by modulating tumor‐associated macrophage phenotypes, influencing tumor growth and immune responses. ABSTRACT Polyamine metabolism is a key regulator of cellular proliferation and immune modulation, and its dysregulation is implicated in multiple carcinoma ...
Haoran Ding +8 more
wiley +1 more source
The intrinsic expression of NLRP3 in Th17 cells promotes their protumor activity and conversion into Tregs. [PDF]
Cell Mol ImmunolAccogli T +17 more
europepmc +1 more source
Plasma IL4 Levels Linked to Pulmonary Hypertension Severity and Outcome
Clinical and Experimental Pharmacology and Physiology, Volume 52, Issue 6, June 2025.ABSTRACT Background The anti‐inflammatory cytokine interleukin‐4 (IL4) has been recognised as a protective factor in various cardiovascular events, yet its prognostic value in patients with pulmonary hypertension (PH) remains unclear. The study aimed to measure the levels of plasma IL4 in patients with PH and to explore their potential association with
Yun Li +11 more
wiley +1 more source
<i>Porphyromonas gingivalis</i> exacerbates experimental autoimmune encephalomyelitis by driving Th1 differentiation via ZAP70/NF-κB signaling. [PDF]
Front ImmunolDai D +7 more
europepmc +1 more source
Type 2 Inflammation and Its Role in Dermatologic Diseases
International Journal of Dermatology, Volume 64, Issue 6, Page 978-991, June 2025.ABSTRACT Atopic dermatitis, prurigo nodularis, and chronic spontaneous urticaria are immune‐mediated, inflammatory skin conditions characterized by intense itch and disease‐specific skin lesions. Despite their different clinical presentations, the three diseases are unified by an aberrant type 2 immune response involving type 2 cytokines, immune cells,
Raj Chovatiya +5 more
wiley +1 more source
Correction: Progress of CCL20-CCR6 in the airways: a promising new therapeutic target. [PDF]
J Inflamm (Lond)Li Y- +5 more
europepmc +1 more source
The FASEB Journal, Volume 39, Issue 10, 31 May 2025.We hypothesize that myeloid‐derived suppressor cells (MDSCs) might be able to ameliorate pulmonary fibrosis (PF) by inhibiting local inflammation and thus its transition to fibrosis. Various parameters were assessed on days 3, 7, 14, and 21, following bleomycin challenge in mice.
Nora Vedder +8 more
wiley +1 more source
TLR5 activation in respiratory epithelial cells orchestrate mucosal Th17 response through both indirect and direct pathways. [PDF]
Respir ResHuang S +10 more
europepmc +1 more source
Loss of ADAP1/CentA1 Protects Against Autoimmune Demyelination
The FASEB Journal, Volume 39, Issue 9, 15 May 2025.ADAP1/CentA1 is an actin‐binding protein highly expressed in neurons. Our study describes a novel immunomodulatory function for ADAP1/CentA1 in the context of autoimmune demyelination. Mice lacking ADAP1/CentA1 were found partially resistant to the multiple sclerosis (MS) model experimental autoimmune encephalomyelitis (EAE) due to an altered ...
Jonathan J. Carver +6 more
wiley +1 more source
Psoriasis in Obese Adolescents with Diabetes-From Common Molecular Background to Vicious Circle of Metabolic Syndrome-Case Report and Review of Literature. [PDF]
CellsBielach-Bazyluk A +5 more
europepmc +1 more source