Results 321 to 330 of about 709,386 (365)

Polyfunctional CD8+CD226+RUNX2hi effector T cells are diminished in advanced stages of chronic lymphocytic leukemia

Molecular Oncology, Volume 19, Issue 5, Page 1347-1370, May 2025.
CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar, Shima Shahbaz, Anthea C. Peters, Spencer B. Gibson, Shokrollah Elahi   +4 more
wiley   +1 more source

Supplementation with active vitamin D3 ameliorates experimental autoimmune thyroiditis in mice by modulating the differentiation and functionality of intrathyroidal T-cell subsets. [PDF]

Front Immunol
Wang CM, Chen YJ, Yang BC, Yang JW, Wang W, Zeng Y, Jiang J.   +6 more
europepmc   +1 more source

Cystatin A promotes the antitumor activity of T helper type 1 cells and dendritic cells in murine models of pancreatic cancer

Molecular Oncology, Volume 19, Issue 5, Page 1452-1470, May 2025.
Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti, Shingo Inagaki, Tuyen Thuy Bich Ho, Akihiro Seki, Keiko Yoshida, Kosuke Satomura, Yoshio Sakai, Shuichi Kaneko, Taro Yamashita   +8 more
wiley   +1 more source

IL-6/IL-12 superfamily of cytokines and regulatory lymphocytes play critical roles in the etiology and suppression of CNS autoimmune diseases. [PDF]

Front Immunol
Yadav MK, Singh SP, Egwuagu CE.
europepmc   +1 more source

Short‐Chain Fatty Acids Modulate Anti‐ROR1 CAR T‐Cell Function and Exhaustion in an Intestinal Adenocarcinoma‐on‐Chip Model

Advanced Healthcare Materials, Volume 14, Issue 13, May 16, 2025.
Short‐chain fatty acids modulate anti‐ROR1 chimeric antigen receptor (CAR) T‐cell function in an intestinal adenocarcinoma‐on‐chip model. Butyrate and propionate reduce cytotoxicity, cytokine release, and infiltration by inducing a regulatory T‐cell phenotype and T‐cell exhaustion via histone deacetylase inhibition.
Valentin D. Wegner, Adrian Feile, Miriam Alb, Michael Hudecek, Philip Hewitt, Alexander S. Mosig   +5 more
wiley   +1 more source

Unleashing the Potential: Exploring the Application and Mechanism of Mesenchymal Stem Cells in Autoimmune Diseases. [PDF]

Stem Cells Int
Li X, Li R, Huang J, Hu Y, Fan C, Wang X, Yu H.   +6 more
europepmc   +1 more source

X-chromosome-linked miR-542-5p as a key regulator of sex disparity in rats with adjuvant-induced arthritis by promoting Th17 differentiation. [PDF]

Biomark Res
Yang JJ, Li Z, Wang LN, Huang BX, Ng JPL, Xu XF, Wang YP, Zhang DW, Qin B, Zhang DQ, Liu C, Luo WD, Law BYK, Wang HM, Liu MH, Yun XY, Chan JTW, Wu WY, Li YT, Cheung PKF, Pou MC, Ha KS, Ao Ieong WF, Leong CH, Leong KI, Lei CW, Cheang LH, Wong VKW.   +27 more
europepmc   +1 more source

Regulatory B cells attenuate sepsis-associated pancreatic injury by regulating T cell homeostasis. [PDF]

Sci Rep
Liu P, Xiao Z, Lu X, Zhang X, Huang J.
europepmc   +1 more source

Immune Modulation Through Stereotactic Radiotherapy: The Role of TBX21, GATA-3, FoxP3, and RORɣt. [PDF]

Medicina (Kaunas)
Ucgul AN, Bora H, Yaz Aydin G, Gulbahar O, Koken UH.   +4 more
europepmc   +1 more source

Tertiary lymphoid structures in colorectal cancer - organization and immune cell interactions. [PDF]

Am J Clin Exp Immunol
Gulubova MV, Valkanov SP, Ignatova MMK, Minkov GA.   +3 more
europepmc   +1 more source