Results 211 to 220 of about 158,259 (287)

Elimination of Chlamydia muridarum from the female reproductive tract is IL-12p40 dependent, but independent of Th1 and Th2 cells. [PDF]

PLoS Pathog
Rixon JA, Fong KD, Morris C, Nguyen AT, Depew CE, McSorley SJ.   +5 more
europepmc   +1 more source

Anti‐CD47 antibody‐decorated and cisplatin‐containing mesoporous silica nanoparticles for targeted chemoimmunotherapy of colorectal cancer in a patient‐derived organoids xenograft model

Interdisciplinary Medicine, EarlyView.
Upon targeted binding to CD47‐overexpressing colorectal cancer (CRC) cells, the nanoparticles disrupt signal regulatory protein α‐CD47 signaling and allow for the restoration of innate immune response by tumor‐associated macrophages (TAMs) against CRC.
Albert Yu, Yibo Hou, Kaibin Huang, Xucan Gao, Rong Zeng, Chaowei Zhu, Chunhui Sun, Guocai Wang, Lei Ye, Shaohua Ma, Tian Meng, Bing Guo, Yubo Zhang, Xiaoyong Dai   +13 more
wiley   +1 more source

Anti-IL-4 antibody treatment prevents the induction of inflammatory bowel disease (IBD) in T-cell receptor (TCR) alpha chain-deficient (α−/−) mice by suppressing the effect of TH2 predominated CD4+ TCR βdim T cells

, 1998
Hiroshi Iijima, Isamu TAKAHASHI, Seiji Kawano, Kazuya Nagano, Makoto Hori, Hiroshi Kiyono   +5 more
openalex   +1 more source

Inflammatory bowel disease and metabolic reprogramming: From pathological mechanisms to targeted interventions

Interdisciplinary Medicine, EarlyView.
This review explores the role of metabolic reprogramming in inflammatory bowel disease (IBD) by focusing on immune and epithelial cell metabolism, microbial metabolites, and their impact on inflammation. It discusses emerging metabolic therapies and emphasizes the importance of personalized microbiota‐targeted approaches to improve clinical outcomes in
Zemin Tian, Yinde Huang, Ying Wang, Chenyu Zhao, Zhaokai Zhou, Hua Yang, Yuan Qiu   +6 more
wiley   +1 more source

Conditional Deletion of Histone Deacetylase 1 in T Cells Leads to Enhanced Airway Inflammation and Increased Th2 Cytokine Production [PDF]

, 2010
Reinhard Grausenburger, Ivan Bilić, Nicole Boucheron, Gordin Zupkovitz, Lamia El-Housseiny, Roland Tschismarov, Yu Zhang, Martina Rembold, Martin Gaisberger, Arnulf Hartl, M. Epstein, Patrick Matthias, Christian Seiser, Wilfried Ellmeier   +13 more
openalex   +1 more source

Reference Intervals for Lymphocyte Subpopulations in Healthy Chinese Han Adults: A Single‐Center Study

Journal of Clinical Laboratory Analysis, EarlyView.
Correlation matrix analysis of lymphocyte parameters. The correlation matrix showed the positive (red) or negative (blue) correlation of two parameters; the color intensity reflected the correlation coefficient. Conducting lymphocyte testing in health management can help monitor immune status, evaluate health risks, analyze pathogenesis of diseases ...
An‐Na Jiang, Lin‐Zi Miao, Yan Gong, Ran You, Yao Lu, Chen‐Xue Qu   +5 more
wiley   +1 more source

Probiotic consumption reduces alveolar bone loss and kidney damage in pregnant rats with experimental periodontitis

Journal of Periodontology, EarlyView.
Abstract Background Bifidobacterium animalis subsp. lactis HN019 (B. lactis HN019) is a probiotic bacterial strain with immunomodulatory properties. Its benefits have been observed in healthy and systemically compromised animals with periodontitis (PD). Our objective was to investigate the local and systemic effects of the systemic administration of B.
Átila V. V. Nobre, Pedro H. F. Silva, Marina C. G. Del‐Arco, Raquel F. Gerlach, Rene S. Oliezer, José E. Tanus‐Santos, Luciene C. Figueiredo, Janaina S. A. M. Evangelista, Flávia A. C. Furlaneto, Michel R. Messora, Sérgio Luiz Salvador   +10 more
wiley   +1 more source

Dextran sodium sulfate confounds causal role of periodontitis in inflammatory bowel disease

Journal of Periodontology, EarlyView.
Abstract Background Emerging evidence supports a bidirectional link between periodontitis and inflammatory bowel disease (IBD). To investigate this relationship, experimental models commonly use dextran sodium sulfate (DSS) to induce colitis. However, DSS is presumed to selectively affect the colon, and its potential off‐target effects on the oral ...
Himanshi Tanwar, Jeba Mercy Gnanasekaran, Niyant Ganesh, Cindy Zhou, Amy Plotkin, Giacomo Baima, Massimo Costalonga, Fenfen Zhou, Hanping Feng, Priyam Jani, Jean‐Pierre Raufman, Vivek Thumbigere‐Math   +11 more
wiley   +1 more source

Amphiregulin-producing T_H2 cells facilitate esophageal fibrosis of eosinophilic esophagitis. [PDF]

J Allergy Clin Immunol Glob
Kaneko T, Iwamura C, Kiuchi M, Kurosugi A, Onoue M, Matsumura T, Chiba T, Nakayama T, Kato N, Hirahara K.   +9 more
europepmc   +1 more source

Beyond eosinophils: A proteomic dissection of remodeling and inflammation in suspected eosinophilic esophagitis

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Eosinophilic esophagitis (EoE) is characterized by eosinophilic inflammation and epithelial remodeling. However, current biomarkers focus predominantly on eosinophilia, overlooking basal cell hyperplasia (BCH), a histologic feature that may persist despite treatment.
Adi Eindor‐Abarbanel, Nimrod Moss‐ Ophir, Netanel Agajany, Daniel L. Cohen, Vered Richter, Haim Shirin, Efrat Broide, Tzippora Shalem   +7 more
wiley   +1 more source