Advanced Science, EarlyView.Eosinophils play a crucial role in the progression of temporomandibular joint osteoarthritis (TMJOA). This study demonstrates that eosinophils, induced by OVA/IL‐5, promote Lumican secretion in the synovium, which binds to Annexin A1 in chondrocytes, inhibiting transforming growth factor β2 and Smad2/3 phosphorylation.
Wenqian Chen +12 more
wiley +1 more source
Th2 cells inhibit growth of colon and pancreas cancers by promoting anti-tumorigenic responses from macrophages and eosinophils. [PDF]
Br J Cancer, 2023 Jacenik D, Karagiannidis I, Beswick EJ.
europepmc +1 more source
Controlling tissue size by active fracture [PDF]
arXivGroups of cells, including clusters of cancerous cells, multicellular organisms, and developing organs, may both grow and break apart. What physical factors control these fractures? In these processes, what sets the eventual size of clusters? We develop a framework for understanding cell clusters that can fragment due to cell motility using an active ...
arxiv
Ability of tolerized Th1 and Th2 clones to stimulate B cell activation and cell cycle progression
, 1992 Kathleen M. Gilbert +4 more
openalex +1 more source
Crossregulation between T helper cell (Th)1 and Th2: inhibition of Th2 proliferation by IFN-gamma involves interference with IL-1. [PDF]
, 1997 Timothy B. Oriss +4 more
openalex +1 more source
Plac1+ Tumor Cell‐Treg Interplay Supports Tumorigenesis and Progression of Head and Neck Cancer
Advanced Science, Volume 12, Issue 17, May 8, 2025.Meng et al. screen genes in the CTAs family and find Plac1 is specifically expressed in head and neck squamous cell carcinoma (HNSCC) cells. They reveal that Plac1 expression promotes HNSCC progression directly by activating PI3K/AKT signaling pathway.
Xiaoyan Meng +8 more
wiley +1 more source
Berberine promotes immunological outcomes and decreases neuroinflammation in the experimental model of multiple sclerosis through the expansion of Treg and Th2 cells. [PDF]
Immun Inflamm Dis, 2023 Tavaf MJ +7 more
europepmc +1 more source
Switch of CD4+ T Cell Differentiation from Th2 to Th1 by Treatment with Cathepsin B Inhibitor in Experimental Leishmaniasis [PDF]
, 1998 Yoichi Maekawa +8 more
openalex +1 more source
Advanced Science, Volume 12, Issue 14, April 10, 2025.Pancreatic cancer promotes the accumulation of mast cells in the tumor microenvironment. Tumor‐derived exosomes deliver miR‐188‐5p to tumor‐associated mast cells (TAMCs), enhancing TAMCs‐derived CXCL10 secretion by strengthening ERG transcription. TAMCs‐derived CXCL10 promotes tumor migration, stemness, and immunosuppressive environment.
Hanlin Yin +20 more
wiley +1 more source