Results 211 to 220 of about 160,112 (257)

TH2 and ‘TH2-like’ cells in allergy and asthma: pharmacological perspectives

Trends in Pharmacological Sciences, 1994
Recently, considerable progress has been made in understanding the molecular basis by which cytokines released from CD4+ helper T cells contribute to allergic disease. A subset of CD4+ helper T cells, termed TH2 cells, produce interleukin 4 (IL-4) and IL-5, but not interferon gamma.
G P, Anderson, A J, Coyle
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Markers of Th1 and Th2 Cells

1996
Markers of TH1 and TH2 lymphocyte subpopulations.
ALMERIGOGNA, FABIO, D'ELIOS, MARIO MILCO, DE CARLI M., DEL PRETE, GIANFRANCO   +3 more
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An Update on Human Th1 and Th2 Cells

International Archives of Allergy and Immunology, 2009
The existence of functionally polarized human T cell responses based on their profile of cytokine secretion in both the CD4+ T helper (Th) and the CD8+ T cytotoxic cell subset has been established. Human Th1 and Th2 cells not only produce a different set of cytokines but also exhibit distinct functional properties and preferential expression of some ...
ROMAGNANI, SERGIO, PARRONCHI, PAOLA, D'ELIOS, MARIO MILCO, ROMAGNANI, PAOLA, ANNUNZIATO, FRANCESCO, PICCINNI, MARIE-PIERRE, R. MANETTI, SAMPOGNARO, SALVATORE, MAVILIA, CARMELO, M. DE CARLI, MAGGI, ENRICO, DEL PRETE, GIANFRANCO   +11 more
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Th1/Th2 Cells

Inflammatory Bowel Diseases, 1999
A large body of evidence indicates the existence of functionally polarized CD4+ T-cell responses based on their profile of cytokine secretion. Type 1 T helper (Th1) cells produce interferon-gamma, interleukin (IL)-2, and tumour necrosis factor (TNF)-beta, which activate macrophages and are responsible for cell-mediated immunity and phagocyte-dependent ...
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Targeting Th2 Cells in Asthmatic Airways

Current Drug Target -Inflammation & Allergy, 2004
The most effective anti-asthmatic drugs currently available include inhaled beta2-agonists and glucocorticoids and control asthma in about 95% of patients. The current asthma therapies are not cures and symptoms return soon after the treatment is stopped even after long-term therapy.
Gaetano, Caramori, Kazuhiro, Ito, Ian M, Adcock   +2 more
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Crossregulation Between Th1 and Th2 Cells

Critical Reviews™ in Immunology, 1998
Th1 and Th2 subsets have been characterized on the basis of the cytokines they secrete and the immune functions they mediate. Th1 cells secrete IL-2, IFN-gamma, and lymphotoxin and are important in the cell-mediated response; Th2 cells secrete IL-4, IL-5, IL-10, and IL-13 and are important in the control of macrophage function and in the stimulation of
P A, Morel, T B, Oriss
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Initiation and maintenance of Th2 cell identity

Current Opinion in Immunology, 2008
T helper type 2 (Th2) cells produce IL-4, IL-5, and IL-13 and play an important role in humoral immunity and allergic reactions. During Th2 cell differentiation, naïve CD4 T cells acquire 'Th2 cell identity', that is, the capability to produce selectively a large amount of Th2 cytokines. Th2 cell identity is maintained in memory Th2 cells.
Toshinori, Nakayama, Masakatsu, Yamashita   +1 more
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Biology of human TH1 and TH2 cells

Journal of Clinical Immunology, 1995
Evidence is accumulating to suggest the existence of polarized human T-cell responses, reminiscent of TH1 and TH2 subsets described for mouse T cells. Human TH1 cells preferentially develop during infections by intracellular bacteria and trigger phagocyte-mediated host defense, whereas TH2 cells, which predominate during helminthic infestations and in ...
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Th2 Cells: Orchestrating Barrier Immunity

2004
Publisher Summary This chapter summarizes recent insights regarding the generation of T helper (Th) 2 cells and factors regulating expression of IL-4—the canonical cytokine secreted by these cells. Th2 cells orchestrate a stereotyped cell response characterized by eosinophil and basophil infiltration, mast cell hyperplasia, and changes in epithelial ...
Daniel B, Stetson, David, Voehringer, Jane L, Grogan, Min, Xu, R Lee, Reinhardt, Stefanie, Scheu, Ben L, Kelly, Richard M, Locksley   +7 more
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Targeting Th2 Cells in Asthmatic Airways

2010
Asthma represents a profound worldwide public health problem. The most effective anti-asthmatic drugs currently available include inhaled β2 -agonists and glucocorti-coids; these control asthma in about 90–95% of patients. However, the future therapies will need to focus on the 5–10% patients who do not respond well to these treatments and who account ...
CARAMORI, Gaetano, Ito K, CASOLARI, Paolo, CONTOLI, Marco, PAPI, Alberto, Adcock IM   +5 more
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