Results 171 to 180 of about 311,380 (392)

Absence seizures: Update on signaling mechanisms and networks

open access: yesEpilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

Perampanel as a second‐line therapy to midazolam reduces soman‐induced status epilepticus and neurodegeneration in rats

open access: yesEpilepsia Open, EarlyView.
Abstract Objective A benzodiazepine (diazepam or midazolam) is one of the current standards of care therapies to effectively terminate organophosphorus nerve agent‐induced status epilepticus when administered shortly after onset. Preclinical studies showed that benzodiazepines were less effective in stopping status epilepticus when treatment was ...
Hailey G. Steier   +8 more
wiley   +1 more source

Cognitive outcomes after deep brain stimulation in drug‐resistant epilepsy: A comparison of anterior thalamic and hippocampal stimulation

open access: yesEpilepsia Open, EarlyView.
Abstract Objective Deep brain stimulation (DBS) of the anterior thalamic nucleus (ATN) and hippocampus is an emerging therapy for drug‐resistant epilepsy (DRE) when resective surgery is not feasible. We aimed to evaluate the long‐term cognitive outcomes of these two DBS targets, hypothesizing that both interventions preserve cognitive function ...
Seonjeong Kim   +5 more
wiley   +1 more source

Abnormalities of thalamus and thalamocortical pathways in patients with refractory epilepsy caused by focal cortical dysplasia – MRI study

open access: yesEpilepsia Open, EarlyView.
Abstract Objective Drug‐resistant epilepsy, a severe and diagnostically challenging neurological condition often linked to focal cortical dysplasia (FCD), represents a significant social and healthcare burden. While the thalamus is notably altered in this disorder, it remains unclear whether these changes result from epilepsy manifestation or ...
David Kala   +12 more
wiley   +1 more source

The Regulatory Role of the Human Mediodorsal Thalamus

open access: yesTrends in Cognitive Sciences, 2018
G. Pergola   +8 more
semanticscholar   +1 more source

Neurobiology and Cognition in Girls at High‐Risk of Eating Disorders: Exploring Imaging‐Derived Trait Markers

open access: yesEuropean Eating Disorders Review, EarlyView.
ABSTRACT Background Eating disorders (EDs) are serious psychiatric disorders characterized by impairments in neurocognition and altered brain structure. To date the majority of studies have investigated these in acutely ill or recovered individuals.
E. Pappaianni   +6 more
wiley   +1 more source

Hypothalamic Astrocytes Exhibit Glycolytic Features Making Them Prone for Glucose Sensing

open access: yesGlia, EarlyView.
Hypothalamic astrocytes versus cortical astrocytes: are more glycolytic due to high Pkm2, Glut1 and Mct4 expression do not exhibit glutamate‐induced glycolysis detect glucose concentration variations via an AMPK sensor with altered lactate production. ABSTRACT In the hypothalamus, detection of energy substrates such as glucose is essential to regulate ...
Sarah Geller   +11 more
wiley   +1 more source

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