Results 161 to 170 of about 181,456 (327)

Digenic Functional B12 and Folate Defect Mimicking Myelodysplasia

Clinical Case Reports, Volume 14, Issue 2, February 2026.
Proposed mechanistic model of mutation‐related outcomes. ABSTRACT A digenic defect involving CUBN and MTHFR produced functional B12/folate deficiency in a patient with pancytopenia and neurological signs, mimicking myelodysplasia. Genetic and metabolic screening revealed elevated methylmalonic acid/homocysteine, with rapid remission post‐parenteral B12.
Thomas Cluzeau, Abderrahim Oussalah, Maël Silva Rodriguez, Mourad Naïmi   +3 more
wiley   +1 more source

Vildagliptin and Omarigliptin Differentially Bind to DPP‐4 Homodimers and Modulate Osteoclast‐Mediated Bone Resorption

Comprehensive Physiology, Volume 16, Issue 1, February 2026.
Vildagliptin and omarigliptin, dipeptidyl peptidase‐4 (DPP‐4) inhibitors, have differential effects on bone cells. Although vildagliptin improved the bone microstructure of high‐fat diet‐fed rats, it was unable to downregulate osteoclastogenesis or the expression of key osteoclast transcripts.
Ratchaneevan Aeimlapa, Jiraporn Panmanee, Jarinthorn Teerapornpuntakit, Kannikar Wongdee, Jirawan Thongbunchoo, Nattapon Panupinthu, Saovaros Svasti, Nattayaporn Apaijai, Piangkwan Sa‐nguanmoo, Siriporn Chattipakorn, Nipon Chattipakorn, Narattaphol Charoenphandhu   +11 more
wiley   +1 more source

Application of third-generation sequencing technology in the genetic testing of thalassemia

Molecular Cytogenetics
Thalassemia is an autosomal recessive genetic disorder and a common form of Hemoglobinopathy. It is classified into α-thalassemia and β-thalassemia. This disease is mainly prevalent in tropical and subtropical regions, including southern China.
Weihao Li, Yanchou Ye
doaj   +1 more source

Conformational lock and thermal inactivation kinetics of Euphorbia amine oxidase [PDF]

The kinetics of thermal inactivation of copper-containing amine oxidase from euphorbia latex (ELAO) were studied in a 100-mM sodium phosphate buffer, pH 7, using cadavarine as the substrate.
امانی, مجتبی, صبوری, علی اکبر, فلوریس, جیووانی, لونگو, سیلویا, مورا, آنا, موسوی موحدی, علی اکبر, موسوی نژاد, سیده زهرا   +6 more
core  

Archipelago Method for Variant Set Association Test Statistics

Genetic Epidemiology, Volume 50, Issue 1, February 2026.
ABSTRACT Variant set association tests (VSAT), especially those incorporating rare variants via variant collapse, are invaluable in genetic studies. However, unlike Manhattan plots for single‐variant tests, VSAT statistics lack intrinsic genomic coordinates, hindering visual interpretation.
Dylan Lawless, Ali Saadat, Mariam Ait Oumelloul, Luregn J. Schlapbach, Jacques Fellay   +4 more
wiley   +1 more source

Identification of a Neonate with Thalassemia Intermedia Despite Premarital Screening Program in Mazandaran Province (Co-inheritance of Hb Knossos and IVS II-1 G> A Mutations)

Research in Molecular Medicine, 2017
Background: Beta thalassemia is a common health problem in Iran especially in Northern provinces. Premarital screening for thalassemia is compulsory in Iran and identification of the carriers is based on primary CBC (Cell Blood Count) and hemoglobin ...
Hossein Karami, Hossein Jalali, Mehrad Mahdavi, Mohammad Reza Mahdavi   +3 more
doaj  

Recent Insights Into Circulating Adipokines in Obesity: Systematic Review and Meta‐Analysis

Obesity Science &Practice, Volume 12, Issue 1, February 2026.
ABSTRACT Background Adipokines are dysregulated in obesity and exacerbate proinflammatory conditions. Although several studies have investigated adipokine levels in obesity, their findings have been inconsistent, leaving the precise nature of these alterations uncertain.
Sunita Sunita, Mohammad Ghozali, Mohammad Rizki Akbar, Annisa Dewi Nugrahani, Iis Inayati Rakhmat, Siti Nur Fatimah, Yuni Susanti Pratiwi, Eko Fuji Ariyanto, Gaga Irawan Nugraha, Mas Rizky A. A. Syamsunarno, Tri Hanggono Achmad   +10 more
wiley   +1 more source

Unstable Hemoglobin, a Rare but Significant Cause of Hemolytic Anemia: Recognition of Peripheral Smear Findings Is Crucial for Diagnosis

International Journal of Laboratory Hematology, EarlyView.
Ryan C. Shean, Archana Agarwal, Anton V. Rets   +2 more
wiley   +1 more source

Is Ferroptosis the Mechanistic Bridge Connecting Iron Dysregulation to Muscle Wasting and Functional Decline in Aging?

Aging Cell, Volume 25, Issue 2, February 2026.
This work proposes ferroptosis as a mechanistic driver of age‐related muscle dysfunction, whereby iron dyshomeostasis and impaired antioxidant capacity promote lipid peroxidation, and eventually trigger ferroptosis, leading to muscle wasting, and ultimately contributing to weakness and functional decline with aging.
Rola S. Zeidan, Simon Reinhard, Anna Picca, Emanuele Marzetti, Christiaan Leeuwenburgh, James F. Collins, Stephen D. Anton   +6 more
wiley   +1 more source

Receptor‐Dependent and ‐Independent Effects of Hemin on Platelet Plasma Membrane Disintegration

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
Microhemorrhages lead to the release of erythrocytes, which are then degraded and lysed. These hemolyses result in the liberation of free iron‐containing hemin. Hemin induces platelet activation and ferroptosis. Inhibition of GPVI/CLEC‐2 receptor‐mediated ITAM‐signaling inhibits hemin‐induced platelet activation (low hemin concentrations). Deferoxamine,
Zoi Laspa, Anne‐Katrin Rohlfing, Ravi Hochuli, Pamela Weronika Sowa, Tatsiana Castor, Meinrad Paul Gawaz   +5 more
wiley   +1 more source