Results 11 to 20 of about 138,095 (212)
Annals of Saudi Medicine, 2013 BACKGROUND AND OBJECTIVES: Authors and team members of the Dubai Thalassemia Centre obtained data on the prevalence of iron overload complications among patients with β-thalassemia major (β-TM) and compared it to international data to improve patient ...
Khawla Mohammed Belhoul +5 more
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Transcriptional Repressors of Fetal Globin Genes as Novel Therapeutic Targets in Beta-Thalassemia [PDF]
, 2020 During development the human β-globin gene cluster undergoes two switching processes at the embryo-fetal and fetal-adult stages, respectively, involving changes in chromatin remodeling and in transcriptional regulatory networks. In particular, during the
Raffaele Sessa +8 more
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, 2023 Genetic polymorphisms in Quantitative Trait Loci (QTL) genes such as BCL11A, HBS1L-MYB and KLF1 have been reported to influence fetal hemoglobin (HbF) levels.
Kausik Mandal +4 more
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Update in Laboratory Diagnosis of Thalassemia
Frontiers in Molecular Biosciences, 2020 Alpha- and β-thalassemias and abnormal hemoglobin (Hb) are common in tropical countries. These abnormal globin genes in different combinations lead to many thalassemic diseases including three severe thalassemia diseases, i.e., homozygous β-thalassemia ...
Thongperm Munkongdee +4 more
doaj +1 more source
Case Reports in Genetics, 2023 Up to now, more than 300 pathogenic variants have been identified in the β-globin gene, some of which are categorized as silent mutations that do not change the hematological indices.
Hossein Jalali +3 more
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, 2023 Introduction Splenomegaly and hypersplenism are common complications of thalassemia patients due to the excessive clearance of defective red blood cells from the spleen.
Shang H. (16810938) +9 more
core +1 more source
Pediatrics In Review, 2012 Thalassemia is the most common form of inherited anemia worldwide. The World Health Organization reports suggest that about 60,000 infants are born with a major thalassemia every year. Although individuals originating from the tropical belt are most at risk, it is a growing global health problem due to extensive population migrations. Despite important
openaire +5 more sources
Hematology Reports, 2019 We propose using a modified amplification refractory mutation system real-time polymerase chain reaction (ARMS RTPCR) technique to exclude the invasive prenatal diagnosis for a non-paternally inherited beta thalassemia mutation in couples atrisk for ...
Narutchala Suwannakhon +6 more
doaj +1 more source
An overview of complications associated with deferoxamine therapy in thalassemia [PDF]
Journal of Nephropharmacology, 2021 Thalassemic syndromes are the most common genetic diseases in the world that are related to blood transfusion and iron overload in the body. In ß-thalassemia major multiple blood transfusions due to ineffective erythropoiesis lead to iron excess in the ...
Bijan Keikhaei +5 more
doaj +1 more source
Fertility in Patients with Thalassemia and Outcome of Pregnancies: A Turkish Experience
Turkish Journal of Hematology, 2019 Objective: In recent years, the rates of marriage and pregnancy are increasing in patients with thalassemia major. The aim of the present study was to investigate the fertility rate of thalassemic patients and the course of pregnancies in terms of mother
Burcu Akıncı +8 more
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