Results 11 to 20 of about 140,652 (287)

Factors Contributing to Improved Bone Mineral Density in Patients With Transfusion-Dependent Thalassemia. [PDF]

Kaohsiung J Med Sci
ABSTRACT Advances in therapy have extended the life expectancy of patients with thalassemia to near that of the general population; complications such as endocrine disorders and osteoporosis remain prevalent. This study aimed to identify endocrine complications, factors associated with endocrine complications, and changes in bone mineral density (BMD ...
Hsu CY, Hsiao HP, Chiou SS, Lin PC, Liao YM, Hsu WY, Wang TH, Wang SY.   +7 more
europepmc   +2 more sources

Phenotypic and Genotypic Analysis of Two Rare Cases of ‐‐SEA/‐α4.3HbH Disease [PDF]

J Clin Lab Anal
We report two unrelated adult patients with rare deletional HbH disease (genotype ‐‐SEA/‐α4.3). This novel 4.3 kb deletion covering the HBA1 gene is accompanied by X‐Y‐Z segment recombination, which was identified by CycloneSEQ long‐read nanopore sequencing.
Yang W, Huang X, Zhang L, Yang X, Guo Y, Kang Q, Dou M, Huang G.   +7 more
europepmc   +2 more sources

Highlights on the Luspatercept Treatment in Thalassemia

, 2023
Luspatercept has been shown to act as a ligand trap, selectively suppressing the deleterious effects of GDF11 that blocks terminal erythroid maturation, restoring normal erythroid differentiation and improving anemia in animal models of &beta ...
Yesim Aydinok, Aydinok, Yesim
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Thalassemia (Beta-Thalassemia)

International Journal For Multidisciplinary Research, 2023
Thalassemia is an inherited blood disorder characterized by less oxygen carrying protein (Haemoglobin) and fever red blood cells in the body than normal. There are mainly two types of thalassemia i.e. Alpha and Beta thalassemia about 1-5% of the global population 80-90 million people are the carrier of ß thalassemia which is major concern.
Tathe Pratiksha Annasaheb -, Gosavi Pratiksha Pramod -, Dr.Gajanan sanap -   +2 more
openaire   +1 more source

Supplementary Material for: Analysis of hematological indices and splenectomy rates in 2,130 patients with Hemoglobin H diseases or β-thalassemia

, 2023
Introduction Splenomegaly and hypersplenism are common complications of thalassemia patients due to the excessive clearance of defective red blood cells from the spleen.
Shang H. (16810938), Ye Y. (3230418), Li P. (4157617), Xu X. (2878946), Qin L. (4762131), Zhang X. (3333504), Wang L. (3116751), Xiao B. (16810941), Li Y. (3218205), Zhang Y. (2828780)   +9 more
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Thalassemia ENDOCRINOPATHIES IN THALASSEMIA PATIENTS

PAFMJ, 2021
Objective: To determine the common endocrine complications found in children having thalassemia major. Study Design: Cross-sectional study. Place and Duration of Study: Department of Pediatric Medicine, Combined Military Hospital Multan, from May to Nov 2019. Methodology: A total of 160 Children with thalassemia were taken in this ...
Umer Touheed, Samra Maryam, Hafiz Muhammad Murtaza, Muhammad Mujtaba Sabir, Lutfullah Goheer, Aamir Aslam Awan   +5 more
openaire   +3 more sources

Mentorship in hematology: A multigenerational perspective on its role in shaping the future of the field. [PDF]

Hemasphere
HemaSphere, Volume 10, Issue 10, October 2026.
Bou-Fakhredin R, Cappellini MD, Taher A.
europepmc   +2 more sources

Multisystem Complications in Non-Transfusion-Dependent β-Thalassemia Intermedia: A Case Highlighting the Need for Early Intervention. [PDF]

Clin Case Rep
ABSTRACT This case highlights that severe complications of non‐transfusion‐dependent β‐thalassemia may be preventable with appropriate monitoring and timely intervention; however, once established, multisystem complications can be challenging to treat.
Aloosh O, Hosseini SE, Karimi M.
europepmc   +2 more sources

Right ventricular volumes and function in thalassemia major patients in the absence of myocardial iron overload [PDF]

, 2010
Aim: We aimed to define reference ranges for right ventricular (RV) volumes, ejection fraction (EF) in thalassemia major patients (TM) without myocardial iron overload.Methods and results: RV volumes, EF and mass were measured in 80 TM patients who had ...
Maciej Garbowski, Maceira, A, Francisco Alpendurada, Banya Winston, He, T, Taigang He, Carpenter, JP, Smith, GC, Kirk, P, Shah, F, Maceira Alicia, Porter, JB, John B Porter, Banya, W, He Taigang, Walker, JM, Kirk Paul, Alicia Maceira, Alpendurada Francisco, Gillian C Smith, Porter John B, Smith Gillian C, Farrukh Shah, Pennell, DJ, Shah Farrukh, Pennell Dudley J, Deac Monica, Dudley J Pennell, Alpendurada, F, Paul Kirk, Winston Banya, Carpenter John-Paul, John-Paul Carpenter, Deac, M, J Malcolm Walker, Garbowski, M, Walker J Malcolm, Garbowski Maciej, Monica Deac   +38 more
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Whole exome sequencing and rare variant association study to identify genetic modifiers, KLF1 mutations, and a novel double mutation in Thai patients with hemoglobin E/beta-thalassemia

, 2023
Clinical manifestations of patients with Hemoglobin E/beta-thalassemia vary from mild to severe phenotypes despite exhibiting the same genotype. Studies have partially identified genetic modifiers.
Kittiphong Paiboonsukwong (5774672), Nawaporn Tansiri (14836554), Surasak Sawatnatee (14836557), Wikanda Pholmoo (14836590), Supawee Saengboon (13010646), Kanyaporn Charoenprasert (14836566), Wichuda Thamprasert (14836569), Nisachon Khorwanichakij (14836581), Chayamon Takpradit (14836560), Narumol Nolwachai (14836572), Wannaphorn Rotchanapanya (6280742), Saranya Pongudom (14836563), Wanlapa Rattanasawat (14836575), Noppadol Siritanaratkul (6413990), Bhoom Suktitipat (202143), Putchong Saetow (14836584), Chanin Limwongse (145689), Krittichat Kamjornpreecha (14836587), Manop Pithukpakorn (744798), Boonyanuch Dujjawan (14836593), Yingyong Chinthammitr (11857510), Busakorn Sae-Aeng (14836578), Chattree Hantaweepant (14836551)   +22 more
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