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PATHOPHYSIOLOGY OF THALASSEMIA
Annals of the New York Academy of Sciences, 1980The clinical manifestations in homozygous thalassemia may be attributed to the defect in hemoglobin synthesis (Figure 16). It is best typified by beta thalassemia, where excess alpha chains accumulate to form intracytoplasmic erythrocytic inclusions. This leads to anemia, bone marrow hyperplasia, osteoporosis, hemosiderosis, and organ failure.
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Archives of Internal Medicine, 1967
ALTHOUGH thalassemia is usually considered to be a disease of the Mediterranean people, it has been described in many racial and ethnic groups.1In particular, McFarland and Pearson recently reported six individuals with this disease, none of whom stemmed from the Mediterranean area.2 Among races and ethnic groups where thalassemia has been found is ...
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ALTHOUGH thalassemia is usually considered to be a disease of the Mediterranean people, it has been described in many racial and ethnic groups.1In particular, McFarland and Pearson recently reported six individuals with this disease, none of whom stemmed from the Mediterranean area.2 Among races and ethnic groups where thalassemia has been found is ...
openaire +3 more sources