Results 51 to 60 of about 114,325 (234)

Prime editing in neuropsychiatric disorders: From mutation‐specific target selection to clinical translation

Neuroprotection, EarlyView.
Abstract Prime editing, a novel clustered regularly interspaced short palindromic repeats (CRISPR)‐based technology, fuses a reverse transcriptase (RT) to an engineered CRISPR‐associated protein 9 (Cas9) and uses a prime editing guide RNA (pegRNA)‐encoded template.
Tianshan Ji, Yuan Zhang, Jinyi Zhao, Yiping Lu, Chengkun Wang   +4 more
wiley   +1 more source

PAIN MANAGEMENT IN PATIENTS WITH SICKLE CELL DISEASE – A REVIEW [PDF]

European Medical Journal Hematology, 2013
Pain is defined, by the International Association for the Study of Pain (IASP), as an ‘unpleasant sensitive and emotional experience, associated with or described in terms of tissue lesion’.
Sophia Delicou, Konstantinos Maragkos
doaj  

Next‐Generation Paleopathology: Using Commercial AI in Bioarchaeological Diagnosis

International Journal of Osteoarchaeology, EarlyView.
ABSTRACT Artificial intelligence encompasses computational systems capable of performing cognitive functions such as learning, reasoning, and problem‐solving. Within this domain, generative AI and large language models such as ChatGPT, Gemini, and Copilot have shown significant potential in clinical diagnostics.
Jessica Mongillo, Giulia Vescovo, Giulia Manzo, Nicoletta Zedda, Barbara Bramanti   +4 more
wiley   +1 more source

Fluconazole as primary antifungal prophylaxis for pediatric hematopoietic stem cell transplant in antifungal NA ÆVE patients

Pediatric Hematology Oncology Journal, 2022
Amit Jain, Rajesh Patil, Ratna Sharma, Pranoti Kini, Ashutosh Walawalkar, Poulami Das, Srishti Srivastava, Leo Prince, Mamta Manglani   +8 more
doaj   +1 more source

Warfare, Labor, and Urban Stress: Divergent Health Trajectories in Mongol‐Period Karakorum

International Journal of Osteoarchaeology, EarlyView.
ABSTRACT This study examines major palaeopathological trends in Mongol‐period Karakorum and incorporates them into the existing body of research in order to deepen our understanding of health and survival, the impacts of conflict and violence on past populations, and the lived experiences of the city's diverse inhabitants within the broader socio ...
Júlia Olive‐Busom, Susanne Reichert, Dunburee Batsukh, Jan Bemmann, Alice Toso   +4 more
wiley   +1 more source

Heterozygous Beta‐Thalassaemia in Pregnancy: Two Rare Causes of Severe Fetal Anemia Requiring Intrauterine Blood Transfusions

Prenatal Diagnosis, EarlyView.
ABSTRACT Aim In this article, we present two cases of severe fetal hemolytic anemia based on a beta‐thalassaemia trait inherited from a single parent. Results These cases, presented at 20 and 28 weeks' gestation, necessitated intra‐uterine blood transfusions.
Eva van der Meij, Frans J. W. Smiers, Tamara T. Koopmann, Ingrid Krapels, Kaatje LePoole, Enrico Lopriore, Johanna M. Middeldorp, Claudia S. Ootjers, Volkher Scharnhorst, Hubertina C. J. Scheepers, Cornelis L. Harteveld, E. J. T. (Joanne) Verweij   +11 more
wiley   +1 more source

Diagnosis and Management of Prenatal Hereditary Pyropoikilocytosis

Prenatal Diagnosis, EarlyView.
ABSTRACT Hereditary pyropoikilocytosis (HPP) is a severe hemolytic anemia caused by variants in SPTA1, SPTB, and EPB41. These weaken horizontal interactions in the erythrocyte cytoskeleton, causing membrane fragmentation and splenic sequestration. It will readily cause fetal anemia and often hydrops fetalis. Prenatal diagnosis requires first ruling out
Connor Hartzell, Samantha Stover, Nora Gibson, Timothy Olson, James Connelly, Matthew Grace, Jennifer Andrews   +6 more
wiley   +1 more source

Inherited thrombocytopenias: Early diagnosis for optimum treatment

Pediatric Hematology Oncology Journal, 2022
Anagha Kulkarni, Amit Jain, Poulami Das, Krisha Shah, Ashutosh Walawalkar, Pranoti Kini, Ratna Sharm, Mamta Manglani   +7 more
doaj   +1 more source

Diagnostic Value of Fructosamine and Glycosylated Hemoglobin in Estimating Blood Glucose Level in Diabetic Patients with Thalassemia Major

Medical Laboratory Journal, 2013
Background and Objective: Diabetes mellitus is one of complications that thalassemia major patients face with. Hence, blood glucose monitoring is of vital importance to these patients.
M Kosaryan, MR, A Aliasgharian, M Mousavi, P Roshan   +4 more
doaj  

Functional correction and genome integrity with duplex base editing of β-thalassemic hematopoietic stem cells

Genome Biology
Background Beta-thalassemia is among the most common monogenic disorders, posing a major global health challenge. Editing of genetic modifiers, such as BCL11A erythroid enhancer and HBG promoters, enhances fetal hemoglobin expression and confers major ...
Nikoletta Y. Papaioannou, Petros Patsali, Julia Klermund, Panayiota L. Papasavva, Geoffroy Andrieux, Lola Koniali, Basma Naiisseh, Soteroula Christou, Maria Sitarou, Marina Kleanthous, Toni Cathomen, Carsten W. Lederer   +11 more
doaj   +1 more source