Results 81 to 90 of about 158,916 (259)

The Evolving Pharmacotherapeutic Landscape for the Treatment of Sickle Cell Disease. [PDF]

, 2020
Sickle cell disease (SCD) is an extremely heterogeneous disease that has been associated with global morbidity and early mortality. More effective and inexpensive therapies are needed.
Ballas, Samir K
core   +1 more source

Cross Sectional Study of Prenatal Diagnosis Uptake Among Individuals With Genetic Conditions

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective Prenatal diagnostic genetic testing allows for early identification of significant fetal conditions and enables informed decision‐making regarding management options. The aim of this study was to assess prenatal testing practice among individuals with genetic conditions.
Ebunoluwa Ojo, Roni Zemet, Allyson Nevins, Katherine Abraham, April D. Adams   +4 more
wiley   +1 more source

Fluconazole as primary antifungal prophylaxis for pediatric hematopoietic stem cell transplant in antifungal NA ÆVE patients

Pediatric Hematology Oncology Journal, 2022
Amit Jain, Rajesh Patil, Ratna Sharma, Pranoti Kini, Ashutosh Walawalkar, Poulami Das, Srishti Srivastava, Leo Prince, Mamta Manglani   +8 more
doaj   +1 more source

Perceptions of thalassemia and its treatment among Malaysian thalassemia patients: A qualitative study [PDF]

, 2016
Background Thalassemia is a common public health problem in Malaysia and one of the most common chronic and genetic disorders. Aims The present qualitative study explores knowledge about thalassemia, perceptions about conventional therapies and the ...
Ahmad Hassali, Mohamed Azmi, Aljadhey, Hisham, Farooqui, Maryam, Ismail, Wan Ismahanisa, Saleem, Fahad   +4 more
core   +2 more sources

Iron(III)-chelating resins X. Iron detoxification of human plasma with iron(III)-chelating resins [PDF]

, 1993
Iron detoxification of human blood plasma was studied with resins containing desferrioxamine B (DFO) or 3-hydroxy-2-methyl-4(1H)-pyridinone (HMP) as iron(III)-chelating groups.
Bantjes, A., Does, L. van der, Feng, M.
core   +3 more sources

On‐Chip Evaluation of Red Blood Cell Deformability Through Transit Velocity Index in Hematological Diseases

Small, EarlyView.
The deformability of red blood cell is essential for smooth microcirculation. We propose a deformability index using a microfluidic platform with capillary‐like constrictions, based on the relationship between cell deformation and transit velocity through the constrictions. Its effectiveness and clinical potential have been demonstrated in applications
Kenji Kajitani, Chia‐Hung Dylan Tsai, Tomohito Ohtani, Shigeo Wada, Ivan Cimrák, Misato Chimura, Tatsunori Taniguchi, Yasutaka Ueda, Jun‐ichi Nishimura, Yasushi Sakata   +9 more
wiley   +1 more source

Assessment of Grades of Recommendations and Applicability of Royal College of Obstetricians and Gynaecologists Green‐Top Guidelines: A Cross‐Sectional Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Background Royal College of Obstetricians and Gynaecologists (RCOG) Green‐top Guidelines (GTGs) provide evidence‐based recommendations in women's health. Even where evidence is considered high quality, it is uncertain whether factors known to influence maternity outcomes are reflected in study design.
Anangsha Kumar, Alexandra Cocking, Megan Hall, James Morris, Srividhya Sankaran, Holly Lovell, Andrew Shennan, Kypros Nicolaides, Lisa Story   +8 more
wiley   +1 more source

Diagnostic Value of Fructosamine and Glycosylated Hemoglobin in Estimating Blood Glucose Level in Diabetic Patients with Thalassemia Major

Medical Laboratory Journal, 2013
Background and Objective: Diabetes mellitus is one of complications that thalassemia major patients face with. Hence, blood glucose monitoring is of vital importance to these patients.
M Kosaryan, MR, A Aliasgharian, M Mousavi, P Roshan   +4 more
doaj  

Functional correction and genome integrity with duplex base editing of β-thalassemic hematopoietic stem cells

Genome Biology
Background Beta-thalassemia is among the most common monogenic disorders, posing a major global health challenge. Editing of genetic modifiers, such as BCL11A erythroid enhancer and HBG promoters, enhances fetal hemoglobin expression and confers major ...
Nikoletta Y. Papaioannou, Petros Patsali, Julia Klermund, Panayiota L. Papasavva, Geoffroy Andrieux, Lola Koniali, Basma Naiisseh, Soteroula Christou, Maria Sitarou, Marina Kleanthous, Toni Cathomen, Carsten W. Lederer   +11 more
doaj   +1 more source

Iron Physiology and Its Impact on Atopic Diseases: An EAACI Taskforce Report

Allergy, EarlyView.
ABSTRACT Iron is essential for oxygen transport, energy metabolism, and immune regulation. Yet iron deficiency is the most common micronutrient disorder across all age groups, affecting nearly one quarter of the global population. Iron deficiency triggers nutritional immunity, a host defense mechanism that withholds and redistributes iron, contributing
Franziska Roth‐Walter, Ioana Agache, Beatriz Cabanillas, Roberto Berni Canani, Pasquale Comberiati, Holger Garn, Cristina Gomez‐Casado, Karin Hufnagl, Ekaterina Khaleva, Gregorio P. Milani, Daniel Munblit, Nikolaos Douladiris, Liam O'Mahony, Frank Redegeld, Carmen Riggioni, Peter K. Smith, Betty van Esch, Emilia Vassilopoulou, Carina Venter, Diego G. Peroni   +19 more
wiley   +1 more source