Results 61 to 70 of about 694,655 (127)

Sickle cell anaemia with and without crises: An observational study of pregnancy outcomes

British Journal of Haematology, EarlyView.
Summary We assessed the pregnancy outcomes of patients with sickle cell crises. We carried out a retrospective study of 2 698 556 pregnancies in Quebec, Canada between 1989 and 2022. The primary exposure was sickle cell anaemia with crisis during or outside of pregnancy. Outcomes included severe maternal morbidity and other pregnancy complications.
Nathalie Auger, Émilia Mailhot‐Diaferia, Gabriel Côté‐Corriveau, Gilles Paradis, Antoine Lewin, Aimina Ayoub, Anne‐Marie Parrot, Ashley Park, Brian Potter   +8 more
wiley   +1 more source

THALASSEMIA MINOR SCREENING APPLICATION USING THE C4.5 METHOD BASED ON LARAVEL [PDF]

Thalassemia is an inherited blood disorder that causes anaemia and weak red blood cells. Thalassemia minor is a type of thalassemia where the patient is a carrier of thalassemia and only experiences mild anaemia.
Wijayanto, Bangun, Kurniawan, Yogiek Indra, Sohputro, Nicolas   +2 more
core   +1 more source

Examination and Sampling of Chorionic Villi for the Diagnosis of Beta-Thalassemia Major in the First Trimester of Pregnancy in Southwestern Iran [PDF]

Armaghane Danesh Bimonthly Journal, 2023
Background & aim: Beta thalassemia is one of the most common hereditary diseases in Iran. The birth of a child with thalassemia causes many social and economic problems for parents and the health care system.
E Shams, M AllahDadian, Z Yadegari Baharanchi, M Harfsheno   +3 more
doaj  

Off‐Label use of a lumen‐apposing metal stent for refractory pyloric stricture in a toddler

JPGN Reports, EarlyView.
Hamza Hassan Khan, Prateek Wali, Sumant Inamdar   +2 more
wiley   +1 more source

Phase 3, randomised, placebo‐controlled trial of voxelotor for the resolution of leg ulcers in sickle cell disease: RESOLVE

British Journal of Haematology, EarlyView.
In this trial, conducted in Kenya, Nigeria and Brazil, the resolution of leg ulcers was similar between the voxelotor and placebo arms. In the 12‐week blinded period, the number of sickle cell anaemia with crisis events was higher in the voxelotor arm compared to placebo.
Bernhards Ogutu, Janet Oyieko, Halima Bello‐Manga, Adeseye Akinsete, Jessie Githanga, José Valber Lima Meneses, Carolyn Hoppe, Mark W. Davis, Jeremy Rupon, Ching‐Ray Yu, Roberto Pinto, Elena Tudone, Ibrahim Musa Idris, Martin Meremikwu, Aderson da Silva Araújo, Rodolfo D. Cançado, Guilherme Fonseca, Patrícia Santos Resende Cardoso, Obiageli Eunice Nnodu, on behalf of the RESOLVE Investigators   +19 more
wiley   +1 more source

Optimising Haematopoietic Stem Cell Transplantation: Enhancing Myeloablation Sensitivity and Alleviating Anaemia Using Roxadustat (FG‐4592)

Cell Proliferation, EarlyView.
The use of FG‐4592 in the process of myeloablation can promote haematopoietic cell apoptosis for more effective myeloablation, maintain the number of RBC and may create a pluripotent microenvironment suitable for donor cells, so as to enable more effective haematopoietic reconstruction of donor cells in vivo.
Guanheng Yang, Jiahui Wu, Xinbing Guo, Wenchen Shen, Xiao Sang, Xiuli Gong, Shu‐Zhen Huang, Jingzhi Zhang, Fanyi Zeng   +8 more
wiley   +1 more source

Bone minerals in beta-thalassemia minor

, 1995
Homozygous beta-thalassemia is a severe hereditary disorder associated with osteopenia. Recently it was suggested that thalassemia minor may be a risk factor for osteoporosis. The purpose of the present study was to investigate this suggestion.
Glaros, D., Kalef-Ezra, J., Cholevas, V., Challa, A., Lapatsanis, P., Hatzikonstantinou, I., Papaefstathiou, I., Chaliasos, N.   +7 more
core  

Gene Editing for Haemophilia—The Next Frontier

Haemophilia, EarlyView.
ABSTRACT The recently approved haemophilia A and B gene therapies via adeno‐associated virus (AAV) showed a promising therapeutic response after a single injection, but there are still limitations, including the potential loss of transgene expression and restriction in adults.
Mirko Pinotti, Gregory A. Newby, Sundar Selvaraj, Steven W. Pipe   +3 more
wiley   +1 more source

Prevalence of minor Thalassemia in first and second degree relatives of patients with major Thalassemia in Kashan in 1377-78

, 2000
History and Objectives: Minor thalassemia is one of hereditary diseases, due to different prevalence of this disease in first and second degree relatives of patients with major Thalassemia and in order to determine the prevalence of minor thalassemia in ...
Sadr, S.F., Talari, S.A., Zare, M., Afzali, H.   +3 more
core  

Is there an association of giardiasis with beta-thalassemia minor? [PDF]

, 2010
Beta–thalassemia minor is a symptomless carrier state of a hemoglobinopathy which predisposes to bacterial infections. We report three cases presenting with giardiasis, a parasitic infection of gastrointestinal tract caused by Giardia lamblia.
Yakoob, Javed, Shaikh, Hizbullah, Jafri, Wasim   +2 more
core