Results 181 to 190 of about 47,030 (243)

Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN

Science, 2018
Thalidomide-targeted degradation Thalidomide and its analogs improve the survival of patients with multiple myeloma and other blood cancers. Previous work showed that the drugs bind to the E3 ubiquitin ligase Cereblon, which then targets for degradation ...
Quinlan Lloyd Sievers, Georg Petzold, Richard D Bunker   +2 more
exaly   +2 more sources

Some of the next articles are maybe not open access.

Related searches:

Thalidomide in America

Science, 2023
A journalist corrects the record on US exposure A journalist corrects the record on US ...
Jesse Olszynko-Gryn
semanticscholar   +1 more source

Thalidomide for Recurrent Bleeding Due to Small-Intestinal Angiodysplasia.

New England Journal of Medicine, 2023
BACKGROUND Recurrent bleeding from the small intestine accounts for 5 to 10% of cases of gastrointestinal bleeding and remains a therapeutic challenge.
Huimin Chen, Shan Wu, Mingyu Tang, Ran Zhao, Qingwei Zhang, Zi-Hao Dai, Yunjie Gao, Shiming Yang, Zhaoshen Li, Yiqi Du, Aiming Yang, Liang Zhong, Lungen Lu, Leiming Xu, Xizhong Shen, Side Liu, J. Zhong, Xiaobo Li, Hong Lu, Hua Xiong, Yufeng Shen, Haiying Chen, Shuai Gong, Hanbing Xue, Zhizheng Ge   +24 more
semanticscholar   +1 more source

A phase 2 study of thalidomide for the treatment of radiation-induced blood-brain barrier injury

Science Translational Medicine, 2023
Radiation-induced brain injury (RIBI) is a debilitating sequela after radiotherapy to treat head and neck cancer, and 20 to 30% of patients with RIBI fail to respond to or have contraindications to the first-line treatments of bevacizumab and ...
Jinping Cheng, Jingru Jiang, Baixuan He, Wei-Jye Lin, Yi Li, Jing-jing Duan, Honghong Li, Xiaolong Huang, Jinhua Cai, Jiatian Xie, Zhan Zhang, Yuhua Yang, Yongteng Xu, Xia Hu, Minyi Wu, X. Zhuo, Qiang Liu, Zhongshan Shi, Pei Yu, Xiaoming Rong, Xiaojing Ye, P. Saw, Long-Jun Wu, C. Simone, M. Chua, H. Mai, Yamei Tang   +26 more
semanticscholar   +1 more source

Identification of a Primary Target of Thalidomide Teratogenicity

Science, 2010
Takumi Ito, Yuki Yamaguchi, Hiroshi Handa   +2 more
exaly   +2 more sources

Binding and thermodynamic study of thalidomide with calf thymus DNA: Spectroscopic and computational approaches.

International Journal of Biological Macromolecules, 2022
The thalidomide-DNA interactions have been investigated in detail by numerous biophysical techniques such as UV-vis, dye displacement assay, viscosity, cyclic voltammetry, circular dichroism, molecular docking, molecular dynamic simulation, FT-IR and 1H ...
Shama Yasmeen, F. A. Qais, M. Rana, A. Islam, Rahisuddin   +4 more
semanticscholar   +1 more source

THALIDOMIDE

Dermatologic Clinics, 2001
Thalidomide has been successful in the treatment of several dermatologic conditions unresponsive to other agents. Further experience may lead to a better understanding of its mechanism of action in these various diseases. Thalidomide should be considered an extremely valuable therapeutic option in selected patients when the benefits clearly outweigh ...
C L, Radomsky, N, Levine
openaire   +4 more sources

Thalidomide suppresses angiogenesis and immune evasion via lncRNA FGD5-AS1/miR-454-3p/ZEB1 axis-mediated VEGFA expression and PD-1/PD-L1 checkpoint in NSCLC.

Chemico-Biological Interactions, 2021
BACKGROUND Non-small cell lung cancer (NSCLC) accounts for about 80-85% of total lung cancer cases. Identifying the molecular mechanisms of anti-tumor drugs is essential for improving therapeutic effects.
Yang Xia, Wei-Cheng Wang, W-H Shen, Kun Xu, Yangin Hu, Gaoyang Han, Yong-Biao Liu   +6 more
semanticscholar   +1 more source

SALL4 mediates teratogenicity as a thalidomide-dependent cereblon substrate

Nature Chemical Biology, 2018
Xinde Zheng, Gang Lu, Thomas Clayton
exaly   +2 more sources

Thalidomide‐induced teratogenesis: History and mechanisms

Birth Defects Research Part C: Embryo Today Reviews, 2015
Nearly 60 years ago thalidomide was prescribed to treat morning sickness in pregnant women. What followed was the biggest man‐made medical disaster ever, where over 10,000 children were born with a range of severe and debilitating malformations.
Neil A Vargesson
exaly   +2 more sources