Results 191 to 200 of about 47,030 (243)
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Bioorganic chemistry (Print), 2020
Thalidomide and its analogs are immunomodulatory drugs that inhibit the production of certain inflammatory mediators associated with cancer. In the present work, a new series of thalidomide analogs was designed and synthesized to obtain new effective ...
M. El-Zahabi +7 more
semanticscholar +1 more source
Thalidomide and its analogs are immunomodulatory drugs that inhibit the production of certain inflammatory mediators associated with cancer. In the present work, a new series of thalidomide analogs was designed and synthesized to obtain new effective ...
M. El-Zahabi +7 more
semanticscholar +1 more source
Journal of Oncology Pharmacy Practice, 2020
Background Thalidomide is the most teratogenic human medicine ever marketed and was associated with birth defects in approximately 10,000 children in the 1960s.
Gedefaw Getnet Amare +2 more
semanticscholar +1 more source
Background Thalidomide is the most teratogenic human medicine ever marketed and was associated with birth defects in approximately 10,000 children in the 1960s.
Gedefaw Getnet Amare +2 more
semanticscholar +1 more source
Thalidomide-Associated Thrombocytopenia
Annals of Pharmacotherapy, 2005OBJECTIVE To report thrombocytopenia in a patient prescribed thalidomide for multiple myeloma (MM). CASE SUMMARY A 70-year-old woman was diagnosed in 2003 with MM. At diagnosis, melphalan 0.25 mg/kg/day and prednisolone 2 mg/kg/day were started; however, the patient became refractory to therapy.
Duyvendak, M +3 more
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BioDrugs, 1999
The major therapeutic effects of thalidomide are the selective inhibition of tumour necrosis factor-alpha production by monocytes and alteration in cellular surface expression of integrins. The major drawbacks of the drug are teratogenicity and irreversible axonal neuropathy.
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The major therapeutic effects of thalidomide are the selective inhibition of tumour necrosis factor-alpha production by monocytes and alteration in cellular surface expression of integrins. The major drawbacks of the drug are teratogenicity and irreversible axonal neuropathy.
openaire +2 more sources
Journal of the peripheral nervous system, 2019
Vinca alkaloids, thalidomide, and eribulin are widely used to treat patients with childhood acute lymphoblastic leukemia (ALL), adults affected by multiple myeloma and locally invasive or metastatic breast cancer, respectively.
Badrul Islam +5 more
semanticscholar +1 more source
Vinca alkaloids, thalidomide, and eribulin are widely used to treat patients with childhood acute lymphoblastic leukemia (ALL), adults affected by multiple myeloma and locally invasive or metastatic breast cancer, respectively.
Badrul Islam +5 more
semanticscholar +1 more source
Reactions Weekly, 2018
In 1962, the United States found itself transfixed by a crisis involving the medication thalidomide. Marketed widely in Europe for a variety of ailments, including nausea during pregnancy, thalidomide turned out to be a severe teratogen, causing thousands of severe birth defects in Germany alone. Yet as a result of diligence by the U.S.
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In 1962, the United States found itself transfixed by a crisis involving the medication thalidomide. Marketed widely in Europe for a variety of ailments, including nausea during pregnancy, thalidomide turned out to be a severe teratogen, causing thousands of severe birth defects in Germany alone. Yet as a result of diligence by the U.S.
openaire +2 more sources
Case report study of thalidomide therapy in 18 patients with severe arteriovenous malformations
Nature Cardiovascular Research, 2022L. Boon +9 more
semanticscholar +1 more source