Results 201 to 210 of about 63,898 (235)
Necrotic erythema nodosum leprosum - A case of severe lepromatous reaction in a multibacillary leprosy patient. [PDF]
IDCasesNagarajan HDP +9 more
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Successful Use of Tofacitinib in Paediatric Prurigo Nodularis: A Report of Four Cases.
Indian J DermatolGowda SK, Ameta B, Garg S, Behera B.
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Dermatologic Clinics, 2001
Thalidomide has been successful in the treatment of several dermatologic conditions unresponsive to other agents. Further experience may lead to a better understanding of its mechanism of action in these various diseases. Thalidomide should be considered an extremely valuable therapeutic option in selected patients when the benefits clearly outweigh ...
C L, Radomsky, N, Levine
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Thalidomide has been successful in the treatment of several dermatologic conditions unresponsive to other agents. Further experience may lead to a better understanding of its mechanism of action in these various diseases. Thalidomide should be considered an extremely valuable therapeutic option in selected patients when the benefits clearly outweigh ...
C L, Radomsky, N, Levine
openaire +2 more sources
Nature, 1963
EARLY in 1962 Prof. Alexander Haddow suggested that we should test thalidomide for carcinogenicity. Accordingly, 20 male mice of the Chester Beatty stock strain were injected subcutaneously in the flank once weekly with 15-mg thalidomide suspended in 0.2 ml. arachis oil.
B. C. V. Mitchley, F. J. C. Roe
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EARLY in 1962 Prof. Alexander Haddow suggested that we should test thalidomide for carcinogenicity. Accordingly, 20 male mice of the Chester Beatty stock strain were injected subcutaneously in the flank once weekly with 15-mg thalidomide suspended in 0.2 ml. arachis oil.
B. C. V. Mitchley, F. J. C. Roe
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Australasian Journal of Dermatology, 2002
SUMMARYThalidomide is an effective agent to treat over 25 seemingly unrelated dermatological conditions that have an inflammatory or autoimmune basis. The main side‐effects of teratogenesis and peripheral neuropathy limit its use. Currently, in Australia no assurance is given as to the quality, safety and efficacy of thalidomide. The use of thalidomide
Michael Wines, Alan Cooper, Nina Wines
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SUMMARYThalidomide is an effective agent to treat over 25 seemingly unrelated dermatological conditions that have an inflammatory or autoimmune basis. The main side‐effects of teratogenesis and peripheral neuropathy limit its use. Currently, in Australia no assurance is given as to the quality, safety and efficacy of thalidomide. The use of thalidomide
Michael Wines, Alan Cooper, Nina Wines
openaire +3 more sources
The International Journal of Biochemistry & Cell Biology, 2007
Over the past 50 years, thalidomide has been a target of active investigation in both malignant and inflammatory conditions. Although initially developed for its sedative properties, decades of investigation have identified a multitude of biological effects that led to its classification as an immunomodulatory drug (IMiD). In addition to suppression of
Magda Melchert, Alan F. List
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Over the past 50 years, thalidomide has been a target of active investigation in both malignant and inflammatory conditions. Although initially developed for its sedative properties, decades of investigation have identified a multitude of biological effects that led to its classification as an immunomodulatory drug (IMiD). In addition to suppression of
Magda Melchert, Alan F. List
openaire +3 more sources
Pediatrics, 1962
THALIDOMIDE [alpha (N-phthalimido) glutarimide] is a synthetic drug with the structural formula shown in Figure 1. Thalidomide was invented by the firm of Chemie Grünenthal as a sedative, but when tested on animals was found to be ineffective. Chemie Grünenthal was, however, so certain that thalidomide must have some quieting effect on the central ...
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THALIDOMIDE [alpha (N-phthalimido) glutarimide] is a synthetic drug with the structural formula shown in Figure 1. Thalidomide was invented by the firm of Chemie Grünenthal as a sedative, but when tested on animals was found to be ineffective. Chemie Grünenthal was, however, so certain that thalidomide must have some quieting effect on the central ...
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Clinical Pharmacology & Therapeutics, 1973
The association between thalidomide and phocomelia was discovered because of the rarity of phocomelia. When we give a drug to a pregnant woman we are also giving it to the fetus whether we want to or not. We must therefore insist that every precaution be taken to identify possible harm to the fetus before any new drug is released.
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The association between thalidomide and phocomelia was discovered because of the rarity of phocomelia. When we give a drug to a pregnant woman we are also giving it to the fetus whether we want to or not. We must therefore insist that every precaution be taken to identify possible harm to the fetus before any new drug is released.
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, 1999 Thalidomide was developed in 1958 by Chemie Grunenthal as an oral sedative. Subsequently, McBride (1) and Lenz (2) described the association between maternal usage of thalidomide and fetal limb defects. The effect of thalidomide as a teratogen was experimentally confirmed in a number of species (3–8).
Taturo Udagawa +2 more
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Drug News & Perspectives, 2002
The first paper describing the pharmacological actions of thalidomide was published in 1956. The drug, then designated as K17, was thought to have sedative effects superior to those of comparator drugs and was thought to be virtually nontoxic. Only 2 years after thalidomide's launch as Contergan in Germany, it's alleged lack of toxicity came into ...
openaire +3 more sources
The first paper describing the pharmacological actions of thalidomide was published in 1956. The drug, then designated as K17, was thought to have sedative effects superior to those of comparator drugs and was thought to be virtually nontoxic. Only 2 years after thalidomide's launch as Contergan in Germany, it's alleged lack of toxicity came into ...
openaire +3 more sources