Results 121 to 130 of about 55,807 (287)

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

open access: yesAdvanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang   +15 more
wiley   +1 more source

FAAS determination of thallium after preconcentration using nitroso-S and TDBA onto benzophenone

open access: yesBulletin of the Chemical Society of Ethiopia, 2005
Thallium is quantitatively retained by 2-nitroso-1-naphthol-4-sulfonic acid (nitroso-S) and tetradecyldimethylbenzylammonium chloride (TDBA) onto benzophenone in the pH range 10.0-11.5 from large volumes of aqueous solutions of various samples.
Mohammad Ali Taher   +2 more
doaj  

Enzymatic Remodelling of Tumour Microenvironment Enhances Anti‐CEACAM5 CAR T‐Cell Efficacy Against Colorectal Cancer

open access: yesAdvanced Science, EarlyView.
This study shows anti‐CEACAM5 CAR T‐cells are ineffective against colorectal cancer (CRC) because of CEACAM5 sequestration at intercellular junctions and the thick tumour cell glycocalyx. Enzymatic treatments of CRC cell monolayer/tissue section with trypsin or hyaluronidase restore CEACAM5 availability, enhance CAR T‐cell activation, increase ...
Debasis Banik   +13 more
wiley   +1 more source

Morphological and Hyperphosphorylation Transitions of Nanoscale Tau Aggregates in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
Super‐resolution microscopy identifies nano‐sized tau aggregates (nano‐aggregates) and reveals distinct transitions in their morphology and phosphorylation profiles across control, Primary Age‐Related Tauopathy, and Alzheimer's disease brains. Morphology and hyperphosphorylation signatures distinguish physiological from pathological forms, with nano ...
Adriana N. Santiago‐Ruiz   +5 more
wiley   +1 more source

Development of Teleoperated Robotic System for Remote Intraocular Microsurgery

open access: yesAdvanced Science, EarlyView.
A teleoperated robotic system, characterized by micrometer‐scale precision and a remote center of motion design, is developed and validated to ensure the safety and flexibility of remote intraocular surgery. This system exhibits superior performance in experimental evaluations and holds significant potential for advancing remote microsurgery ...
Andi Xu   +30 more
wiley   +1 more source

Thallium removal by the montmorillonite biochar composite: insights and environmental implications

open access: bronze, 2022
Eric Cyubahiro   +8 more
openalex   +1 more source

Seipin‐Mediated Lipid Droplet Formation in Cardiomyocytes Ameliorates Cardiac Ischemia/Reperfusion Injury

open access: yesAdvanced Science, EarlyView.
Lipid droplets (LDs) protect the heart against lipotoxicity in cardiac ischemia/reperfusion (I/R) injury; however, they are insufficient to prevent cardiomyocyte death. Seipin plays a central role in the insufficient formation of LDs, subsequent lipotoxicity, and myocardial injury during cardiac I/R injury.
Changyun Liu   +13 more
wiley   +1 more source

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