Results 61 to 70 of about 36,311 (253)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Environmental Research LettersClimate-driven permafrost thaw releases greenhouse gases (CO _2 and CH _4 ). Fully frozen permafrost has extremely low gas permeability, acting as a seal that limits gas migration while low temperatures also inhibit gas generation.
Paul W J Glover +3 more
doaj +1 more source
Journal of Human Reproductive SciencesBackground: A newly developed ready-to-use (RtU) vitrification-warming kit enables vitrification in 12–13 min and thawing in 6 min, thereby simplifying culture operations by reducing overall handling time, but its effects on operability and clinical ...
Yamato Mizobe +2 more
doaj +1 more source
Numerical simulation of moisture migration depending on the rate of soil freezing [PDF]
Инженерно-строительный журнал, 2012 One of the geomechanics challenges is the quantitative assessment of deformation of soils associated with frost heaving and thawing. The main difficulty in solving this problem is the need to consider changing the state of soil freezing and thawing ...
A.V. Kazharskiy, S.A. Kudryavtsev
doaj
, 2017 The effects of conventional-C, carbon fiber plate assisted cabinet heater-CPAC, ohmic-OT, and microwave thawing-MT techniques on changes of some quality characteristics and resistant starch (RS) content of potato (Solanum tuberosum L.) cubes (18 x 18 x ...
Cokgezme, Omer Faruk +2 more
core +1 more source
Size of cryopreserved spheroids after thawing.
, 2020 Spheroid sizes before cryopreservation (A), just after thawing (B), and 3 days after thawing (C) were measured with a measuring system on the bio-3D printer. The spheroid diameter comparison among spheroids before cryopreservation, just after thawing and
Kenichi Arai (6090824) +4 more
core +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Research Advances in the Effect of Dielectric Thawing on the Quality of Raw Meat [PDF]
Thawing is an important unit operation in the processing of frozen meat. Some of the major concerns for its application are thawing duration, temperature uniformity, juice loss, cooking loss, freshness, texture characteristics and taste changes.
ZHANG Xiao, JIN Yamei, WU Yuhang, YAO Huangbing, YANG Na, XU Xueming
core +2 more sources
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source