Results 21 to 30 of about 18,085 (180)

Tau Pathology in Alzheimer's Disease Uniquely Affects Sulcal Depths

Annals of Neurology, Volume 99, Issue 5, Page 1343-1353, May 2026.
Objective Though it is widely known that tau deposition affects brain structure, the precise localization of these effects is poorly understood, especially in relation to gyral and sulcal anatomy. We investigated whether tau pathology in Alzheimer's disease (AD) preferentially affects sulci, and particularly sulcal depths.
Samira A. Maboudian, Corrina S. Fonseca, Adam C. Martersteck, Yishu Chao, Yuheng Chen, Daniela Ushizima, Duygu Tosun, Lea T. Grinberg, Kevin S. Weiner, William J. Jagust, for the Alzheimer's Disease Neuroimaging Initiative   +10 more
wiley   +1 more source

Decline of Visual Function and Risk of Legal Blindness With Age in RPGR ‐Associated Retinal Degeneration: A Multicenter Study

Clinical &Experimental Ophthalmology, Volume 54, Issue 4, Page 482-491, May/June 2026.
ABSTRACT Background This retrospective multicenter longitudinal analysis analysed the loss trajectory of best recorded visual acuity (BRVA) and Goldmann visual field (GVF) in RPGR‐associated retinal degeneration (RPGR‐RD). Methods Patients with genetically confirmed RPGR‐RD were classified into rod‐cone (RC), cone/cone‐rod (CR) and female‐carrier ...
Bela J. Parekh, Joshua D. Stein, Rebhi Abuzaitoun, Chris A. Andrews, Kari Branham, Dejan Milentijevic, Divya Narayanan, Naheed W. Khan, Suzann Pershing, Sophia Y. Wang, Baseer U. Ahmad, Thomas B. Connor, Jennifer L. Patnaik, Marc Mathias, Monique Leys, Brian McMillan, Nnana Amakiri, Taylor J. Johnson, Catherine Q. Sun, Jacque L. Duncan, K. Thiran Jayasundera, on behalf of the SOURCE consortium, Sejal Amin, Paul A. Edwards, Divya Srikumaran, Fasika Woreta, Jeffrey S. Schultz, Anurag Shrivastava, Baseer Ahmad, Louis R. Pasquale, Paul J. Bryar, Dustin D. French, Michelle Hribar, Merina Thomas, Brian L. Vanderbeek, Suzann Pershing, Sophia Y. Wang, Michael Deiner, Catherine Sun, Jennifer Patnaik, Prem Subramanian, Saleha Munir, Wuqaas Munir, Joshua Stein, Lindsey De Lott, Rajeev Ramachandran, Robert Feldman, Brian C. Stagg, Barbara Wirostko, Brian McMillian, Arsham Sheybani, Soshian Sarrapour, Kristen Harris‐Nwanyanwu   +52 more
wiley   +1 more source

Saksan markkinakartoitus - Pole Bicycle Company Oy [PDF]

, 2015
Tämän opinnäytetyön toimeksiantajana toimi suomalainen Pole Bicycle Company Oy. Opinnäytetyön tavoitteena oli kartoittaa Pole Bicycle Companyn edellytyksiä kansainvälistyä Saksan markkina-alueelle.
Korhonen, Ville
core  

Fall experiences of ambulatory children and adults with cerebral palsy: A qualitative study using thematic content analysis

Developmental Medicine &Child Neurology, Volume 68, Issue 5, Page 673-680, May 2026.
Abstract Aim To qualitatively assess the causes, adaptations, and psychosocial impact of falls, and solutions for safer environments, as shared by individuals diagnosed with cerebral palsy (CP). Method Ambulatory adults with CP (n = 165; age median [interquartile range], range: 30 years [25–50], 18–76 years); 101 females, 59 males, five non‐binary/not ...
Marissa Esterley, Linda E. Krach, Kari Pederson, Sandy Callen Tierney, Nathan G. Wandersee, Elizabeth R. Boyer, on behalf of The Cerebral Palsy Research Network   +6 more
wiley   +1 more source

Night‐to‐night rapid eye movement sleep variability: A relevant marker of early amyloid‐β deposition

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION Sleep disturbances are prevalent in patients with Alzheimer's disease (AD) and may emerge before overt clinical symptoms. We characterized sleep alterations in cognitively unimpaired older adults with cerebral amyloid deposition, and assessed their associations with regional amyloid deposition and cognitive and psychoaffective ...
Blandine Montagne, Maéva Boulin, Anaïs Hamel, Pierre Champetier, Stéphane Rehel, Florence Mézenge, Brigitte Landeau, Marion Delarue, Oriane Hébert, Célia Soussi, Françoise Bertran, Gaël Chételat, Claire André, Géraldine Rauchs, the Medit‐Ageing Research Group   +14 more
wiley   +1 more source

AI‐enhanced Centiloid quantification of amyloid PET images

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION The Centiloid scale is the standard for amyloid (Aβ) PET quantification in research and clinical settings. However, variability between tracers and scanners remains a challenge. METHODS This study introduces DeepSUVR, a deep learning method to correct Centiloid quantification, by penalizing implausible longitudinal trajectories ...
Pierrick Bourgeat, Jurgen Fripp, Leo Lebrat, Ying Xia, Azadeh Feizpour, Timothy Cox, Georgios Zisis, Ashley Gillman, Manu S. Goyal, Duygu Tosun, Tammie LS. Benzinger, Pamela LaMontagne, Michael Breakspear, Michelle K. Lupton, Cathy Short, Robert Adam, Joanne S. Robertson, Reisa Sperling, Sid E. O'Bryant, Sterling C. Johnson, Clifford R. Jack Jr, Christopher G. Schwarz, Frederik Barkhof, Gill Farrar, Ariane Bollack, Lyduine E. Collij, Susan Landau, Robert Koeppe, for the Alzheimer's Disease Neuroimaging Initiative, OASIS3, the A4/LEARN Study Team, the AMYPAD consortium, The Health and Aging Brain Study (HABS‐HD) Study Team, Mayo Clinic Study of Aging, WRAP, ADNI‐DOD, PISA, ADNeT, the AIBL research group, John C. Morris, Michael W. Weiner, Victor L. Villemagne, Colin L. Masters, Christopher C. Rowe, Vincent Dore   +44 more
wiley   +1 more source

Gray matter microstructure from in vivo diffusion magnetic resonance imaging reflects post mortem neuropathology severity and clinical progression of Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION Diffusion‐weighted imaging derived mean diffusivity (MD) correlates with Alzheimer's disease (AD) biomarkers, yet its neuropathological correlates remain unclear. METHODS Diffusion‐weighted imaging, post mortem neuropathology, and cognitive performance data were obtained from the National Alzheimer's Coordinating Center (N = 97 ...
Zaki Alasmar, Cécilia Tremblay, Roqaie Moqadam, Geidy E Serrano, Thomas G Beach, Alireza Atri, Yi Su, for the Alzheimer's Disease Neuroimaging Initiative, Yashar Zeighami, Mahsa Dadar   +9 more
wiley   +1 more source

Neurometabolic and vascular dysfunction as an early diagnostic for Alzheimer's disease and related dementias

Alzheimer's &Dementia, Volume 21, Issue 11, November 2025.
Abstract INTRODUCTION Recent studies suggest that the brain undergoes anatomical and functional restructuring, resulting in neurometabolic and vascular dysregulation (MVD) prior to amyloid beta accumulation, which begins at an early age and leads to the onset of Alzheimer's disease (AD).
Juan Antonio K. Chong Chie, Scott A. Persohn, Ravi S. Pandey, Greg W. Carter, Olivia R. Simcox, Paul Salama, Paul R. Territo, for the Alzheimer's Disease Neuroimaging Initiative   +7 more
wiley   +1 more source

ATTRACTIVENESS OF THE AUSTRALIAN UTILITY POLE MARKET : Case Company [PDF]

, 2017
The objective of this thesis was to assess the attractiveness of the Australian utility pole market from the perspective of the case company. A business intelligence influenced the interest about wood poles in Australia.
Adaam, Isaac
core  

Effect of SSRIs on clinical progression in amnestic mild cognitive impairment stratified by Alzheimer's disease pathology

Alzheimer's &Dementia, Volume 21, Issue 11, November 2025.
Abstract INTRODUCTION This study examined whether selective serotonin reuptake inhibitors (SSRIs) treatment influenced cognitive trajectory and progression to Alzheimer's disease (AD) dementia in amnestic mild cognitive impairment (MCI) patients, stratified by AD pathology. METHODS Four hundred fifty‐seven amnestic MCI participants in the ADNI database
Yan Li, Wenying Liu, Xuechu Wang, Wei Qin, Zhaojun Liu, Diyang lyu, Ying Li, Bingqiu Li, Lingzhi Xu, Shuman Cao, for the Alzheimer's Disease Neuroimaging Initiative, Joyce R. F. Chong, Mitchell K. P. Lai, Christopher L. H. Chen, Jianping Jia   +14 more
wiley   +1 more source