Results 101 to 110 of about 128,313,875 (298)

The public discourse on genetics in autism communities: a content analysis of Reddit posts

Current Research in Biotechnology
Purpose: There is ongoing debate in the autism community on the role of genetics. Most research examining the discourse on genetics in autism have focused primarily on caregivers.
Kamil R. Hiralal, Anneke Louwerse, Matea Skojo, Manon H.J. Hillegers, Hugo G. Schnack, Sabine E. Mous, Gwendolyn C. Dieleman   +6 more
doaj   +1 more source

An Anti‐Amyloidogenic Approach to Specifically Block Memory Consolidation in Mice for Therapeutic Intervention

Advanced Science, EarlyView.
Functional amyloid conversion of the translation regulator CPEB3 is essential for long‐term memory persistence. This study demonstrates that targeting this molecular switch with the anti‐amyloidogenic peptide QBP1 selectively blocks CPEB3 fibrillation without disrupting phase separation.
Paula López‐García, Kerry R. McGreevy, Maria Eugenia Vaquero, Juan M. Suarez‐Rivero, Antonio Moreno‐Rodríguez, Antonio J. Pérez‐Pulido, Daniel Ramírez de Mingo, Anna Pallé, Helena Akiko Popiel, Andrea Santi, Mario D. Cordero, José Luis Trejo, Yoshitaka Nagai, Mariano Carrión‐Vázquez   +13 more
wiley   +1 more source

Identifying the gaps: Knowledge, attitudes and practices of urban-based healthcare providers towards adolescent contraception in Jamaica

Caribbean Medical Journal, 2023
Objective: Health care providers (HCPs) may serve as facilitators or barriers to access. We explore the knowledge, attitudes and practices of HCPs in Jamaica to identify gaps which may lead to unmet contraceptive needs for adolescents.
Abigail Harrison, Sheree Mair, Helen Trotman   +2 more
doaj  

The Mind From Within: Visceral Roots of Human Cognition

Advanced Science, EarlyView.
The physiological activity of visceral organs, such as the heart, the lungs, and the gut, is surprisingly linked to many sophisticated mental operations, such as remembering the past, being aware of ourselves, making choices, and forging social bonds.
Alessandro Monti, Salvatore Maria Aglioti   +1 more
wiley   +1 more source

White matter free water and depressive symptoms in medication-free depressed adolescents: moderation by peripheral inflammation

Translational Psychiatry
Major Depressive Disorder (MDD) often emerges during adolescence and significantly impacts psychological and social functioning. Increasing evidence links both peripheral inflammation and white matter abnormalities to the pathophysiology of MDD.
Weicheng Li, Zerui You, Chengyu Wang, Xiaofeng Lan, Fan Zhang, Zhibo Hu, Xiaoyu Chen, Zhanjie Luo, Yexian Zeng, Yiying Chen, Yifang Chen, Siming Mai, Robin Shao, Hanna Lu, Roger S. McIntyre, Xiangdong Sun, Yuping Ning, Yanling Zhou   +17 more
doaj   +1 more source

Resilience in traumatised youth: qualitative study on therapists’ perspectives and practices

European Journal of Psychotraumatology
Background: Research has increasingly focused on how trauma-exposed youth achieve positive adaptation despite adversity, leading to the development of multiple theoretical frameworks of resilience.
Ilse Visser, Rik Knipschild, Malindi van der Mheen, Levi Van Dam, Marleen Wildschut, Ramón J. L. Lindauer, Irma Hein   +6 more
doaj   +1 more source

Targeting the KCNC3‐Dependent Anterior Insular‐Lateral Orbitofrontal Cortex Glutamatergic Circuit Attenuates Post‐Traumatic Anxiety

Advanced Science, EarlyView.
Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li, Xiao‐Bo Qian, Hai‐Long Zhang, Di Li, Ling Ji, Xin‐Chun Xu, Jia‐Sheng Ding, Li‐Jun Yin, Li Zhang, Guang‐Yin Xu, Rong Gao   +10 more
wiley   +1 more source

Does your mother know? : parent-child communication about adolescent daily activities [PDF]

, 2010
Juvenile offending is a wide-spread problem in Western societies: More than half of the adolescents engage in minor forms of delinquency, and this causes high material and immaterial costs.
Dep Educatie & Pedagogiek, Leerstoel Meeus, Keijsers, L., Adolescent development: Characteristics and determinants   +3 more
core   +1 more source

Heat Stress Promotes Fibroblast‐Derived WNT5A Secretion Through m6A Modification to Activate Melanogenesis

Advanced Science, EarlyView.
Heat stress promotes WNT5A secretion from fibroblasts via METTL3/YTHDC1‐dependent m6A methylation. Subsequently, WNT5A binds to FZD10 on melanocytes, activating β‐catenin‐driven melanogenesis. ABSTRACT As the impact of global warming continues to intensify, the effects of heat stress on the skin are becoming increasingly evident.
Yuanyuan Wan, Yaqing Wen, Yushan Zhang, Lan Zhang, Jianjian Zhu, Zhen Tang, Ling Jiang, Chuhan Fu, Shu Zhou, Keyi Zhang, Jiangfeng Huang, Li Lei, Jing Chen, Qinghai Zeng   +13 more
wiley   +1 more source

Autism and mild epilepsy associated with a de novo missense pathogenic variant in the GTPase effector domain of DNM1

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023
Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei, Elena Parrini, Claudia Bianchini, Maria Luisa Ricci, Renzo Guerrini   +4 more
wiley   +1 more source