Results 121 to 130 of about 128,313,875 (298)

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source

Psychometric accuracy of the Dutch Child and Adolescent Trauma Screener

European Journal of Psychotraumatology
Objective: The aim of this study is to investigate the psychometrics of the Dutch version of the Child and Adolescent Trauma Screener (CATS-2). By this, an international recognized instrument to screen symptoms of post-traumatic stress (PTSS) in children
Lieke H. Kooij, Irma M. Hein, Cedric Sachser, Samantha Bouwmeester, Madelief Bosse, Ramón J. L. Lindauer   +5 more
doaj   +1 more source

An Injectable Metal‐Drug Supramolecular Condensate Enables Radiosensitization and Systemic Antitumor Immunity for Post‐Surgical Osteosarcoma Therapy

Advanced Science, EarlyView.
This work designed an injectable metal‐drug supramolecular condensate formed from hafnium ions and alendronate (Hf‐ALN) and loaded with the COX‐2 inhibitor celecoxib (CXB) for synergistic radioimmunotherapy of postoperative osteosarcoma. Mechanistically, upon X‐ray irradiation, Hf enhances radiation energy deposition, ROS generation, and DNA damage ...
Tianhua Xiao, Zunlei Gong, Chuke Chen, Hui Yu, Yu Cai, Can Liu, Hongkai Huang, Ying Li, Jinyuan Guan, Le Wang, Chengyun Ning, Guoxin Tan, Lei Zhou   +12 more
wiley   +1 more source

How are Scotland's young people doing? : A cross-national perspective on physical activity, TV viewing, eating habits, body image and oral hygiene [PDF]

, 2011
The HBSC study in Scotland is funded by NHS Health ...
Smith, R, Alexander, L, Currie, Candace, Todd, J   +3 more
core   +1 more source

Single-cell transcriptional landscape of peripheral myeloid cells in autoimmune diseases

iScience
Summary: Myeloid cells are pivotal in autoimmune disorder development due to their varied immune response functions yet understanding them at the single-cell level in such conditions is limited. To address this gap, we analyzed 351,905 myeloid cells from
Frank Qingyun Wang, Xiao Dang, Caicai Zhang, Huidong Su, Yao Lei, Xinxin Chen, Jing Yang, Wanling Yang   +7 more
doaj   +1 more source

The Adolescent Experience

, 2000
The Adolescent Experience places the college student at the very heart of the book. The authors engage in a dialogue with the reader that is warm, caring, and often humorous as they write and share material about this time of life.
Markstrom, Carol A., Adams, Gerald R., Gullotta, Thomas P.   +2 more
core  

Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex‐Differential Proteins and Candidate Therapeutic Targets

Advanced Science, EarlyView.
An integrated proteogenomic analysis of 44,137 predominantly European‐ancestry UK Biobank participants aged 40–69 years identifies 12 robust proteins associated with idiopathic pulmonary arterial hypertension. These proteins define a high‐mortality molecular endotype, support early detection and mortality prediction, reveal sex‐differential proteomic ...
Xinjie Lin, Yangchang Zhang, Yang Pu, Duanke Liu, Tao Lei, Kai Ma, Qiyu He, Zheng Dou, Yuze Liu, Dengyuan Liu, Yinge He, Yanshang Wang, Xiaojiao Zheng, Yanbing Ma, Jianrong Zhou, Weiding Zhai, Binbin Su, Li Chen, Shoujun Li   +18 more
wiley   +1 more source

Developmental Environmental Chronotoxicity by Polystyrene Nanoplastics Exacerbates High‐Fat Diet‐Induced Pediatric MAFLD Through Circadian Disruption and Mitochondrial Dysfunction

Advanced Science, EarlyView.
Polystyrene nanoplastics exacerbate high‐fat diet‐induced metabolic dysfunction in an age‐dependent manner. Juvenile mice exhibit greater susceptibility, characterized by circadian disruption, impaired mitochondrial function, reduced energy metabolism, and enhanced hepatic lipid accumulation.
Peihao Xu, Shuting Huang, Leilei Zhu, Junyi Huang, Kewei Li, Guangming Li, Jiannong Wu, Mingyuan Zhou, Fangmei Zhou, Zhishan Ding, Yingzhi Shen   +10 more
wiley   +1 more source

Do Universal Free School Meals Improve the Dietary Quality of Food‐At‐Home Purchases?

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT Since 2014, the number of schools offering universal free meals to all enrolled children without requiring annual meal applications has increased meaningfully. Using USDA's Purchase to Plate Crosswalk, a difference‐in‐differences framework, and a nationwide consumer panel, the effect of universal‐free‐meal exposure on the diet quality of food ...
Xueying Ma, Andres Cuadros‐Meñaca, Michael R. Thomsen   +2 more
wiley   +1 more source

SDrecall: a sensitive approach for variant detection in segmental duplications

Genome Biology
Variant calling in segmental duplications is challenging for short-read sequencing because of ambiguous read origins. We present SDrecall, a method for sensitive variant detection in these regions.
Xing Tian Yang, Chun Hing She, CaiCai Zhang, Daniel Leung, Jing Yang, Koon-Wing Chan, Jaime S. Rosa Duque, Yu Lung Lau, Wanling Yang   +8 more
doaj   +1 more source