Results 101 to 110 of about 132,115,309 (296)

TROMSØ DECLARATION On the occasion of the Sixth Ministerial Meeting of The Arctic Council April, 2009 [PDF]

, 2009
TROMSØ DECLARATION On the occasion of the Sixth Ministerial Meeting of The Arctic Council.
Arctic Council, -
core   +1 more source

Bryophyte sedimentary ancient DNA as a proxy for environmental change in northern Fennoscandia

Ecological Indicators
Broad geographic distribution yet narrow habitat tolerances of bryophytes make them sensitive indicators of disturbance and climate change in northern ecosystems.
Dilli Prasad Rijal, Arve Elvebakk, Inger Greve Alsos   +2 more
doaj   +1 more source

Sami yoik, Sami history, Sami health: a narrative review

International Journal of Circumpolar Health, 2018
Music as a possible health-promoting agent has attained increasing academic and scientific interest over the last decades. Nonetheless, possible connections between indigenous singing traditions and health beyond traditional ceremonial healing practices ...
Soile Hämäläinen, Frauke Musial, Anita Salamonsen, Ola Graff, Torjer A. Olsen   +4 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

“I hope to get some hope”: balancing expectations, hope, and acceptance in naturally occurring consultations without a medical diagnosis

International Journal of Qualitative Studies on Health & Well-Being
Background Chronic musculoskeletal pain (CMP) is a prevalent condition often lacking clear biomedical explanations, leading to frustration for both clinicians and patients.
Trine C. B. Andersen, Sarah Nettleton, Åge Wifstad, Olaug S. Lian   +3 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Promotion of beta cell proliferation through DYRK kinase inhibition using the marine natural product breitfussin C

Scientific Reports
Pro-inflammatory cytokines, like interleukin-1 beta and interferon gamma, are known to activate signalling pathways causing pancreatic beta cell death and dysfunction, contributing to the onset of diabetes. Targeting cytokine signalling pathways offers a
Sara Ullsten, Kine Østnes Hansen, Guillaume Axel Petit, Espen Holst Hansen, Jeanette Hammer Andersen   +4 more
doaj   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Senior Arctic Official (SAO) Report to Ministers, Nuuk Greenland, 2011 [PDF]

, 2011
Arctic Council Senior Arctic Officials' (SAO) Report to Ministers.
Arctic Council, -
core   +1 more source

Effects of resource availability and interspecific interactions on Arctic and red foxes' winter use of ungulate carrion in the Fennoscandian low‐Arctic tundra

Ecology and Evolution
In the Arctic tundra, predators face recurrent periods of food scarcity and often turn to ungulate carcasses as an alternative food source. As important and localized resource patches, carrion promotes co‐occurrence of different individuals, and its use ...
Simon Lacombe, Rolf Ims, Nigel Yoccoz, Eivind Flittie Kleiven, Pedro G. Nicolau, Dorothee Ehrich   +5 more
doaj   +1 more source