Results 71 to 80 of about 132,115,309 (296)

INARI DECLARATION 2002 on the occasion of the Third Ministerial Meeting of THE ARCTIC COUNCIL [PDF]

, 2002
INARI DECLARATION on the occasion of the Third Ministerial Meeting of THE ARCTIC COUNCIL, October ...
Arctic Council, -
core   +1 more source

Cervid herpesvirus 2 and not Moraxella bovoculi caused keratoconjunctivitis in experimentally inoculated semi-domesticated Eurasian tundra reindeer

Acta Veterinaria Scandinavica, 2017
Background Infectious keratoconjunctivitis (IKC) is a transmissible disease in semi-domesticated Eurasian reindeer (Rangifer tarandus tarandus). It is regarded as multifactorial and a single causative pathogen has not yet been identified.
Morten Tryland, Javier Sánchez Romano, Nina Marcin, Ingebjørg Helena Nymo, Terje Domaas Josefsen, Karen Kristine Sørensen, Torill Mørk   +6 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Declaration on Establishment of The Arctic Council (The Ottawa Declaration) - 1996 [PDF]

, 1996
The declaration of the establishment of the Arctic ...
Arctic Council, -
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A large-scale multivariate soccer athlete health, performance, and position monitoring dataset

Scientific Data
Data analysis for athletic performance optimization and injury prevention is of tremendous interest to sports teams and the scientific community. However, sports data are often sparse and hard to obtain due to legal restrictions, unwillingness to share ...
Cise Midoglu, Andreas Kjæreng Winther, Matthias Boeker, Susann Dahl Pettersen, Sigurd Pedersen, Nourhan Ragab, Tomas Kupka, Steven A. Hicks, Morten Bredsgaard Randers, Ramesh Jain, Håvard J. Dagenborg, Svein Arne Pettersen, Dag Johansen, Michael A. Riegler, Pål Halvorsen   +14 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Taxonomy of Arctic sea ice-associated rotifers of the genus Synchaeta based on novel 18S and COI sequences and morphological observations

Frontiers in Marine Science
IntroductionThe microscale brine channels in sea ice create a unique habitat for cold-adapted organisms, including invertebrates like rotifers, nematodes, and harpacticoid copepods, collectively known as sympagic (i.e.
Miriam Marquardt, Bodil A. Bluhm, Rolf Gradinger, Andreas Altenburger, Andreas Altenburger   +4 more
doaj   +1 more source

Arctic and Sub-Arctic Bees

Nature, 1898
OF the wild bees of Alaska nothing is known, except that several species of humble-bees (Bombus) are common. Consequently, when Mr. Trevor Kincaid wrote me last year that he was going to Alaska, and would collect bees, I was expecting to see, on his return, quite a new bee-fauna.
openaire   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source