Results 81 to 90 of about 583,007 (361)

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Interaction webs in arctic ecosystems: Determinants of arctic change? [PDF]

Ambio, 2017
How species interact modulate their dynamics, their response to environmental change, and ultimately the functioning and stability of entire communities. Work conducted at Zackenberg, Northeast Greenland, has changed our view on how networks of arctic biotic interactions are structured, how they vary in time, and how they are changing with current ...
Schmidt, Niels M., Hardwick, Bess, Gilg, Olivier, Høye, Toke Thomas, Krogh, Paul Henning, Meltofte, Hans, Michelsen, Anders, Mosbacher, Jesper B., Raundrup, Katrine, Reneerkens, Jeroen, Stewart, Lærke, Wirta, Helena, Roslin, Tomas   +12 more
openaire   +8 more sources

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

EGFR‐STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1‐positive prostate cancer

Molecular Oncology, EarlyView.
Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva, Bernardo Orr, Ana Azeredo, Andreia Brandão, Manuel R. Teixeira, Paula Paulo   +5 more
wiley   +1 more source

Ecosystem drivers of an Arctic fox population at the western fringe of the Eurasian Arctic

Polar Research, 2017
The distribution of traditional breeding dens on the Varanger Peninsula (70–71°N) in northernmost Fennoscandia indicates that this area once harboured a large Arctic fox population.
Rolf A. Ims, Siw T. Killengreen, Dorothee Ehrich, Øystein Flagstad, Sandra Hamel, John-André Henden, Ingrid Jensvoll, Nigel G. Yoccoz   +7 more
doaj   +1 more source

How tropical Pacific surface cooling contributed to accelerated sea ice melt from 2007 to 2012 as ice is thinned by anthropogenic forcing [PDF]

, 2019
Over the past 40 years the Arctic sea ice minimum in September has declined. The period between 2007 and 2012 showed accelerated melt contributed to the record minima of 2007 and 2012.
Baxter, Ian
core  

Seasonal variation of the transport of black carbon aerosol from the Asian continent to the Arctic during the ARCTAS aircraft campaign [PDF]

, 2011
Extensive measurements of black carbon (BC) aerosol were conducted in and near the North American Arctic during the Arctic Research of the Composition of the Troposphere from Aircraft and Satellites (ARCTAS) aircraft campaign in April and June-July 2008.
Blake, DR, Diskin, G, Fuelberg, HE, Koike, M, Kondo, Y, Matsui, H, Moteki, N, Sahu, LK, Sessions, WR, Takegawa, N, Wisthaler, A, Zhao, Y   +11 more
core   +1 more source

The Arctic

Bulletin of the American Meteorological Society, 2023
Moon, Twila, Thoman, R., Druckenmiller, M, Ahmasuk, Brandon, Backensto, Stacia, Ballinger, Thomas, Benestad, Rasmus, Berner, Logan., Bernhard, Germar, Bhatt, Uma, Bigalke, Siiri, Bjerkejarle, W., Brettschneider, Brian, Christiansen, Hanne, Cohen, Judah, Decharme, Bertrand, Derksen, Chris, Divine, Dmitry, Drost, Jensen, Druckenmiller, Matthew, Eliaschereque, Alesksandra, Epstein, Howard, Fausto, Robert, Fettweis, Xavier, Fioletov, Vitali, Forbes, Bruce, Frost, Gerald, Gerland, Sebastian, Goetz, Scott, Grooß, Jens-Uwe, Hanna, Edward, Hanssen-Bauer, Inger, Hendricks, Stefan, Holmes, Robert, Ialongo, Iolanda, Isaksen, Ketil, Johnsen, Bjørn, Jones, Timothy, Kaler, Robb S.A., Kaleschke, Lars, Kim, Seong-Joong, Labe, Zachary, Lader, Rick, Lakkala, Kaisa, Lara, Mark, Lindsey, Jackie, Loomis, Bryant, Luojus, Kari, Macander, Matthew, Mamen, Jostein, Mankoff, Ken, Manney, Gloria, Mcafee, Stephanie, Mcclelland, James, Meier, Walter, Moon, Twila, Moore, G., Mote, Thomas, Mudryk, Lawrence, Müller, Rolf, Nyland, Kelsey, Overland, James, Parrish, Julia, Perovich, Donald, Petersen, Guðrún Nína, Petty, Alek, Phoenix, Gareth, Poinar, Kristin, Rantanen, Mika, Ricker, Robert, Romanovsky, Vladimir, Serbin, Shawn, Serreze, Mark, Sheffield, Gay, Shiklomanov, Alexander, Shiklomanov, Nikolay, Smith, Sharon, Spencer, Robert, Streletskiy, Dmitry, Suslova, Anya, Svendby, Tove, Tank, Suzanne, Tedesco, Marco, Thoman, Richard, Tian-Kunze, Xiangshan, Timmermans, Mary-Louise, Tømmervik, Hans, Tretiakov, Mikhail, Walker, Donald, Walsh, John, Wang, Muyin, Webster, Melinda, Wehrlé, Adrian, Yang, Dedi, Zolkos, Scott, Allen, Jessicca, Camper, Amy, Haley, Bridgette, Hammer, Gregory, Love-Brotak, S., Ohlmann, Laura, Noguchi, Lukas, Riddle, Deborah, Veasey, Sara   +103 more
openaire   +2 more sources

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

Molecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan, Moshe Leitner, Amos Toren, Shoshana Paglin, Michal Yalon   +4 more
wiley   +1 more source

A large-scale multivariate soccer athlete health, performance, and position monitoring dataset

Scientific Data
Data analysis for athletic performance optimization and injury prevention is of tremendous interest to sports teams and the scientific community. However, sports data are often sparse and hard to obtain due to legal restrictions, unwillingness to share ...
Cise Midoglu, Andreas Kjæreng Winther, Matthias Boeker, Susann Dahl Pettersen, Sigurd Pedersen, Nourhan Ragab, Tomas Kupka, Steven A. Hicks, Morten Bredsgaard Randers, Ramesh Jain, Håvard J. Dagenborg, Svein Arne Pettersen, Dag Johansen, Michael A. Riegler, Pål Halvorsen   +14 more
doaj   +1 more source