Results 51 to 60 of about 209,842 (262)
THE SEXUAL ORIENTATION OF A PARENT AS A FACTOR WHEN CONSIDERING CARE
Potchefstroom Electronic Law Journal, 2013 Section 28(2) of the Constitution states that a child's best interest is of paramount importance in every matter concerning the child. Section 9 further provides that every person is considered equal before the law and has the right to equal protection ...
Chantelle Feldhaus +1 more
doaj +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Особливості судового рішення у справах за участі дітей
Наукові записки НаУКМА: Юридичні наукиThe article is devoted to the development of approaches to the consideration of court cases with the participation of children, one of which may be the introduction of special requirements for a court decision that concerns a child, which will help to ...
Pavlo Parkhomenko
doaj +1 more source
Potchefstroom Electronic Law Journal, 2016 Although the contexts of school discipline and child justice differ considerably there are a number of contact points and points that overlap. Since the South African Schools Act 84 of 1996 came into operation in 1996, the Constitutional Court has made ...
Mariëtte Reyneke
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Social SciencesThis study explores judges’ experiences of assessing parental high-conflict cases in Norwegian courts, focusing on dilemmas in applying the principle of the child’s best interests.
Vibeke Samsonsen +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
THE PRINCIPLE OF THE BEST INTERESTS OF THE CHILD [PDF]
Challenges of the Knowledge Society, 2019 Since 1919, the recognition of children's rights has begun to find an international echo, when the League of Nations ”came to life”, the name of which links to the Geneva Declaration of 1924. Adopted in 1989, by the Convention on the Rights of the Child,
Ioana PĂDURARIU
doaj
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source