Results 51 to 60 of about 211,135 (304)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Abduction of a minor and criminal law reaction [PDF]

Zbornik Radova: Pravni Fakultet u Novom Sadu, 2018
Criminal prosecution for the abduction of a minor should additionally protect the child's right to live with his parents, or other authorized caregivers, and also to maintain contact with parents or other relatives and close people. The paper is designed
Kovačević Milica D.
doaj  

THE SEXUAL ORIENTATION OF A PARENT AS A FACTOR WHEN CONSIDERING CARE

Potchefstroom Electronic Law Journal, 2013
Section 28(2) of the Constitution states that a child's best interest is of paramount importance in every matter concerning the child. Section 9 further provides that every person is considered equal before the law and has the right to equal protection ...
Chantelle Feldhaus, Chantelle van den Heever.   +1 more
doaj   +1 more source

[The Best Interest of the Child in Neonatology: Is It Best for the Child?].

Cuadernos de bioetica : revista oficial de la Asociacion Espanola de Bioetica y Etica Medica, 2015
Since its inceptions, the standard of best interest of the child was linked to decisions about suspend life-sustaining treatments in neonatal units and evaluation of treatments applied to children in terms of their quality of life. This origin has conditioned the interpretation of the standard from two extremes: a vitalistic one, and a non vitalistic ...
Di Pietro, Maria Luisa, González Melado, Fermin J.   +1 more
openaire   +2 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Representing the child: the evolution of the guardian ad litem in care proceedings [PDF]

, 1993
The aim of the study is to illuminate the legal, social and administrative context of the "safeguarding" and representational role of the guardian ad litem in care proceedings, a senior social worker appointed by the court to represent
Cooper, Susan A.M.
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Aligning school discipline with the best interests of the child: Some deficits in the legislative framework

, 2017
The best-interest-of-the-child concept should guide the legislative framework with regard to the approach followed as well as the disciplinary processes used in schools.
Reyneke, J. M., J. M. Reyneke, Pretorius, J. L., J. L. Pretorius   +3 more
core   +1 more source

Three perspectives on the notion of ‘the best interests of the child’

In die Skriflig
The research reported in this article was centred on three research questions about the issue of ensuring that, in education and schooling, the principle of the best interests of the child is respected.
Johannes L. Van der Walt, Izak J. Oosthuizen   +1 more
doaj   +1 more source

Realising the Child's Best Interests: Lessons from the Child Justice Act to Improve the South African Schools Act

Potchefstroom Electronic Law Journal, 2016
Although the contexts of school discipline and child justice differ considerably there are a number of contact points and points that overlap. Since the South African Schools Act 84 of 1996 came into operation in 1996, the Constitutional Court has made ...
Mariëtte Reyneke
doaj   +1 more source