Results 61 to 70 of about 1,202,454 (306)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Three perspectives on the notion of ‘the best interests of the child’

In die Skriflig
The research reported in this article was centred on three research questions about the issue of ensuring that, in education and schooling, the principle of the best interests of the child is respected.
Johannes L. Van der Walt, Izak J. Oosthuizen   +1 more
doaj   +1 more source

Realising the Child's Best Interests: Lessons from the Child Justice Act to Improve the South African Schools Act

Potchefstroom Electronic Law Journal, 2016
Although the contexts of school discipline and child justice differ considerably there are a number of contact points and points that overlap. Since the South African Schools Act 84 of 1996 came into operation in 1996, the Constitutional Court has made ...
Mariëtte Reyneke
doaj   +1 more source

'Leaving no stone unturned': contesting the medical care of a seriously ill child [PDF]

, 2017
Recent cases concerning disagreements over the medical treatment of a child with cancer prompt consideration of the effectiveness of the courts in the resolution of conflict over the best interests of a seriously ill child.
Bridgeman, Jo
core  

Deconstructing and Reconstructing Rights for Immigrant Children [PDF]

, 2014
Children rights advocates and scholars alike continue to call for the development of innovative and alternative rights models, which specifically provide for an expansive conceptualization of children’s rights.
Corcoran, Erin B.
core   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

The right to live in a family and the subsidiarity of adoption in the light of the best interests of the childs

Revista Facultad de Jurisprudencia, 2019
Adoption rates in Chile, in relation to the number of children placed in alternative care systems, are considerably low. Although there are a multiplicity of factors that motivate the previous situation, one that we consider of particular relevance, is ...
Alejandra Illanes Valdés
doaj  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Особливості судового рішення у справах за участі дітей

Наукові записки НаУКМА: Юридичні науки
The article is devoted to the development of approaches to the consideration of court cases with the participation of children, one of which may be the introduction of special requirements for a court decision that concerns a child, which will help to ...
Pavlo Parkhomenko
doaj   +1 more source

Judicial implementation of article 3 of the Convention on the Rights of the Child in Europe : the case of migrant children including unaccompanied children [PDF]

, 2012
The United Nations Convention on the Rights of the Child (CRC) and its Optional Protocols provide the basis for establishing effective mechanisms to address the multifaceted challenges faced by States and other actors, including regional organizations ...
Finch, Nadine, Jerónimo, Patrícia
core