Results 91 to 100 of about 128,359,238 (287)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
The Modern Devout and `Private' Religion
, 2006 Lecture held April 6, 2006, 7 p.m. in Woodward Hall, UNM as the final lecture of the Institute for Medieval Studies' Spring Lecture Series 2006.The influential and innovative religious movement known as the Devotio Moderna or "Modern Devotion" first ...
Van Engen, John H.
core
Mapping Global Middle Ages, Toward a Global Middle Ages
, 2019 In Order to understand what a "global Middle Ages" might be, we need to define "global" in and in relation to the "Middle Ages." To do so, I turn to medieval (Christian) maps.
Asa Simon Mittman, Bryan C. Keene
core +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
The Lindisfarne Gospels: The Transforming Power of Sacred Text
, 2006 Lecture held April 4, 2006, 4 p.m. in Woodward Hall, UNM as the second lecture of the Institute for Medieval Studies' Spring Lecture Series 2006.Of all forms of human knowledge, sacred texts may seem to be the least open to change over time.
Brown, Michelle P.
core
Changes in Scale in the Italian Countryside from Late Antiquity to the Early Middle Ages
, 2011 Even if in Italy there is a tendence to emphasize a continuity between the Late Antique era and the Early Medieval Ages, we cannot deny that a radical break took place (on a quantitative as well as a qualitative scale) between the 5th and the 7th ...
CHAVARRIA ARNAU, ALEJANDRA +1 more
core +1 more source