Results 101 to 110 of about 128,359,238 (287)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Interpreting Transformations of People and Landscapes in Late Antiquity and the Early Middle Ages. Archaeological Approaches and Issues

, 2018
In this volume of papers, deriving from two conferences held in Rome and Leicester in 2016, nineteen leading European archaeologists discuss and interpret the complex evolution of landscapes – both urban and rural – across Late Antiquity and the Early ...
Seaman, Andy, Brogiolo, Gian Pietro, Meneghini, Roberto, Vigil-Escalera Guirado, Alfonso, Chavarría Arnau, Alexandra, Raynaud, Claude, Esmonde Cleary, Simon, Collins, Rob, Diarte-Blasco, Pilar, Heeren, Stijn, Arce, Javier, Christie, Neil, Goffredo, Roberto, Ariño, Enrique, Tompkins, Abigail E. I., Olmo Enciso, Lauro, Volpe, Giuliano, Rippon, Stephen, White, Roger   +18 more
core  

Crowd Actions in Britain and France from the Middle Ages to the Modern World

, 2015
Crowd Actions in Britain and France from the Middle Ages to the Modern World explores the lively and often violent world of the crowd, examining some of the key flashpoints in the history of popular action.
Davis, MT
core   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Preface: Special Issue “Geoarchaeology and past human–environment interactions” [PDF]

Eiszeitalter und Gegenwart, 2020
H. von Suchodoletz, H. von Suchodoletz, S. Berg, E. Eckmeier, L. Werther, C. Zielhofer   +5 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Christendom and christianity in the middle ages

, 1993
Though buffetted on all sides by rapid and at times cataclysmic social, political, and economic change, the medieval church was able to make adjustments that kept it from becoming simply a fossil from the past rather than an enduring institution of ...
Bruinsma, Reinder, Bredero, Adriaan H.
core  

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source