Results 131 to 140 of about 299,168 (307)

Precision Lost Wax Casting

open access: yesEXARC Journal, 2012
The limits of precision casting were explored experimentally at the Bronze Casting Workshop at Wilhelminaoord, the Netherlands, by making wax models, moulds and lost wax castings using essentially early metalworking conditions.
Nigel Meeks   +2 more
doaj  

The selected issues of the early middle-ages burial places [PDF]

open access: yes, 2008
I. Introduction. The dissertation paper contains four separate studies dealing with the topíc ofburials in the Early Middle-Ages. The paper's focus is the Czech Early Middle-Ages environment, however, in all studies the author tried to integrate the ...
Štefan, Ivo
core  

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

open access: yesMolecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy   +10 more
wiley   +1 more source

Texts and Identities in the Early Middle Ages

open access: yesBulletin du Centre d’Études Médiévales d’Auxerre, 2008
Régine Le Jan
doaj   +1 more source

We are command of gentilmen : service and support among the lesser nobility of Lothian during the Wars of Independence, 1296-1341

open access: yes, 2012
This thesis examines the political, social and, in particular, military conditions that influenced the allegiance of the men and women of the political community of Lothian, that is to say those people with personal landholding, legal and military ...
Brown, Chris
core  

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Documentary culture and the laity in the early Middle Ages /

open access: yes, 2013
"Many more documents survive from the early Middle Ages than from the Roman Empire. Although ecclesiastical archives may account for the dramatic increase in the number of surviving documents, this new investigation reveals the scale and spread of ...
Kosto, Adam J.,(viaf)59306058   +3 more
core  

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

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