Results 121 to 130 of about 7,085,195 (293)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

THE IMAGE OF THE END OF SECOND WORLD WAR AT EIGHTY YEARS OLD. BETWEEN HISTORICAL ACCURACY AND POLITICAL BIAS

open access: yesAnnals: Series on History and Archaeology (Academy of Romanian Scientists)
Eighty years after the end of the Second World War, all of the warring nations still remember this final tragedy in different ways. Historians from both the West and the Soviet Union/Russia believe that its effects were different.
Constantin Hlihor
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

From Books to the Silver Screen: Transformations of Michael Cunningham’s Fiction

open access: yesAmerican and British Studies Annual, 2008
By 1999 when Michael Cunningham published The Hours not many people had known his name although he had already written two other novels. The success of The Hours followed by a movie of same name made Cunningham world-wide known.
Ivan Burda
doaj  

A Disentangled Recognition and Nonlinear Dynamics Model for Unsupervised Learning

open access: yes, 2017
This paper takes a step towards temporal reasoning in a dynamically changing video, not in the pixel space that constitutes its frames, but in a latent space that describes the non-linear dynamics of the objects in its world.
Fraccaro, Marco   +3 more
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

“Thus Far the Words of Jeremiah” But who gets the last word?

open access: yes, 1999
I\u27ll never forget the first time a movie star talked to me. At the end of his television show, Roy Rogers looked right into the camera and sang to me, Happy trails to you, until we meet again.
Delamarter, Steve
core  

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