Results 131 to 140 of about 577,642 (264)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Medical Fuzzy-Expert System for Assessment of the Degree of Anatomical Lesion of Coronary Arteries. [PDF]

Int J Environ Res Public Health, 2023
Wójcik W, Mezhiievska I, Pavlov SV, Lewandowski T, Vlasenko OV, Maslovskyi V, Volosovych O, Kobylianska I, Moskovchuk O, Ovcharuk V, Lewandowska A.   +10 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Knowledge-Based Expert System for Orthopedic Injury Management With Integrated Transcutaneous Electrical Nerve Simulation Therapy. [PDF]

Int J Telemed Appl
Banjar H, Almalki S, Almehmadi L, Alshahrani A, Chaudhary A, Ghoname R.   +5 more
europepmc   +1 more source

Improving the Trustworthiness of Interactive Visualization Tools for Healthcare Data through a Medical Fuzzy Expert System. [PDF]

Diagnostics (Basel), 2023
Albarrak AM.
europepmc   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

MOSY : A method for synthetic opinions to yield a robust fuzzy expert system. [PDF]

MethodsX, 2023
Gnaneshwara N, Vijay BV.
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Machine learning enhanced expert system for detecting heart failure decompensation using patient reported vitals and electronic health records. [PDF]

Sci Rep
Saha S, Ross H, Velmovitsky PE, Wang CX, Vishram-Nielsen JKK, Manlhiot C, Wang B, Cafazzo JA.   +7 more
europepmc   +1 more source

Using Decision Trees as an Expert System for Clinical Decision Support for COVID-19. [PDF]

Interact J Med Res, 2023
Chrimes D.
europepmc   +1 more source