Results 121 to 130 of about 577,642 (264)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Can a Rule-Based Expert System Diagnose Nasal Obstruction from Nasoendoscopy Videos? [PDF]

Facial Plast Surg
Navaratnam A, Phoommanee N, Acharya V, Pendolino AL, Leung TS, Andrews PJ.   +5 more
europepmc   +1 more source

Computer-aided diagnosis of primary membranous nephropathy using expert system. [PDF]

Biomed Eng Online, 2023
Gao J, Wang S, Xu L, Wang J, Guo J, Wang H, Sun J.   +6 more
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Improving Clinical Decision-Making in Treating Airway Diseases With an Expert System Built Upon the Free AI Tool Google NotebookLM. [PDF]

JMIR Med Inform
Hsu CH, Hsu CL, Tsou CH, Hsu KF, Yang HY.   +4 more
europepmc   +1 more source

IoT Based Expert System for Diabetes Diagnosis and Insulin Dosage Calculation. [PDF]

Healthcare (Basel), 2022
Valsalan P, Hasan NU, Farooq U, Zghaibeh M, Baig I.   +4 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

GPT-4-based AI agents-the new expert system for detection of antimicrobial resistance mechanisms? [PDF]

J Clin Microbiol
Giske CG, Bressan M, Fiechter F, Hinic V, Mancini S, Nolte O, Egli A.   +6 more
europepmc   +2 more sources

An Ontology-Based Expert System Approach for Hearing Aid Fitting in a Chaotic Environment. [PDF]

Audiol Res
Ngounou GM, Chana AM, Batchakui B, Nguen KA, Fokouo Fogha JV.   +4 more
europepmc   +1 more source

A novel optimization method for belief rule base expert system with activation rate. [PDF]

Sci Rep, 2023
Xiang G, Wang J, Han X, Tang S, Hu G.
europepmc   +1 more source