Results 61 to 70 of about 129,030 (245)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

The Effect of Risk Profile, Company Size, Profitability, Liquidity, and Leverage on Firm Value in Mining Companies Listed on the Indonesia Stock Exchange (IDX) in 2022–2024

Danadyaksa
This study aims to examine the effect of risk profile, firm size, profitability, liquidity, and leverage on firm value in mining companies listed on the Indonesia Stock Exchange (IDX) during the 2022–2024 period.
Nila Wahyu Maya Lestari, Elen Puspitasari   +1 more
doaj   +1 more source

The mediation of the effect of leverage on the firm value through earnings management: Empirical evidence from Egypt [PDF]

Maǧallaẗ Al-Buḥūṯ Al-Tiǧāriyyaẗ
This study aims to examine the mediation of the effect of leverage on the firm value through earnings management. I used a sample of 56 companies listed on the Egyptian stock exchange distributed over 7 sectors during the period 2014 to 2019, to ...
شاهنده حامد أمين صيام
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

The Decision Whether to Hire Managers in a Mixed Duopoly with State-Owned and Labor-Managed Firms [PDF]

International Journal of Management, Accounting and Economics, 2020
This paper considers a mixed duopoly model in which a state-owned firm competes with a labor-managed firm. The timing of this game is as follows. In the first stage, each firm decides whether or not to hire a manager.
Kazuhiro Ohnishi
doaj  

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Environmental, social and governance disclosure and firm value in the energy sector: The moderating role of profitability [PDF]

Problems and Perspectives in Management
Environmental, social, and governance (ESG) performance is critical in mitigating climate change. Energy companies must include ESG practices in their business plans because they can determine firm value.
Priskila Dorothy, Endri Endri
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

THE EFFECT OF GROWTH OPPORTUNITY, FIRM SIZE, AND DEBT POLICY ON FIRM VALUE MEDIATED BY PROFITABILITY IN REAL ESTATE AND PROPERTY SECTOR COMPANIES ON THE INDONESIA STOCK EXCHANGE

Russian Journal of Agricultural and Socio-Economic Sciences, 2021
The purpose of this study is to obtain empirical evidence regarding the effect of Growth Opportunity, Firm Size, and Debt Policy on Firm Value, and examine the role of Profitability in mediating the effect of Growth Opportunity, Firm Size, and Debt ...
Janitra P.V.V., Sedana I.B.P.
doaj   +1 more source