Results 71 to 80 of about 223,516 (312)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Simulation of the Colombian Firm Energy Market [PDF]
We present a simulation analysis of the proposed Colombian firm energy market. The main purpose of the simulation is to assess the risk to suppliers of participation in the market.
Peter Cramton +2 more
core
The mediation of the effect of leverage on the firm value through earnings management: Empirical evidence from Egypt [PDF]
Maǧallaẗ Al-Buḥūṯ Al-TiǧāriyyaẗThis study aims to examine the mediation of the effect of leverage on the firm value through earnings management. I used a sample of 56 companies listed on the Egyptian stock exchange distributed over 7 sectors during the period 2014 to 2019, to ...
شاهنده حامد أمين صيام
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
A model of internal firm relocation in the Netherlands [PDF]
This paper presents a model of internal relocation of firms in the Netherlands. Firm relocation is driven both by firm internal factors, such as growth, age, and type of activity, as well as external factors, relating to the business cycle, the ...
Corina Huisman, Leo JG Van Wissen
core
Black gold, the scenic rim and the theory of the firm: implications of the exploration for coal and coal seam gas in the scenic rim of south east Queensland for the evolving theory of the firm [PDF]
, 2016 The implicit social contract between Australian society, government and business does not provide an environment in which communities within the Scenic Rim of South East Queensland believe that their values and development desires are adequately ...
Maddox, Cecil W. E.
core +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Environmental, social and governance disclosure and firm value in the energy sector: The moderating role of profitability [PDF]
Problems and Perspectives in ManagementEnvironmental, social, and governance (ESG) performance is critical in mitigating climate change. Energy companies must include ESG practices in their business plans because they can determine firm value.
Priskila Dorothy, Endri Endri
doaj +1 more source
Gospodarka Narodowa, 2011 International statistics show that small firms are the dominant form of business enterprise today. Yet, despite ongoing research into the theory of the firm, there is still no common view on the mechanisms of firm growth. This article aims to stimulate further theoretical and empirical research into firm growth.
openaire +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source