Results 61 to 70 of about 127,858,707 (311)

Antifouling and pH-Responsive Poly(Carboxybetaine)-Based Nanoparticles for Tumor Cell Targeting

Frontiers in Chemistry, 2019
Nanocarriers with responsibility and surface functionality of targeting molecules have been widely used to improve therapeutic efficiency. Hence, we report the assembly of pH-responsive and targeted polymer nanoparticles (NPs) composed of poly(2 ...
Feng Ding, Shuang Yang, Zhiliang Gao, Jianman Guo, Peiyu Zhang, Xiaoyong Qiu, Qiang Li, Mingdong Dong, Jingcheng Hao, Qun Yu, Jiwei Cui, Jiwei Cui   +11 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Selectivity and Active State Formation During Pulsed CO2 Electroreduction in Cation‐Modified Electrolyte

ChemElectroChem
Pulsed CO2 reduction reaction (CO2RR) is a viable approach to steer selectivity between C1 and C2+ products as well as hydrocarbons and oxygenates via intermittent Cu oxidation.
Eric Liberra, Lichen Bai, Timon Wagner, Ane Etxebarria, Leon Jacobse, Martina Rüscher, Eduardo Ortega, Janis Timoshenko, Arno Bergmann, Beatriz Roldan Cuenya   +9 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Adhesion and adhesion changes at the copper metal-(acrylonitrile-butadiene-styrene) polymer interface

, 2007
It is known that the adhesive strength of metallic films on polymer substrates often changes in the course of time. To study this effect in more detail, the adhesion energy of sputtered and galvanically strengthened copper coatings on acrylonitrile ...
With, de, G., With, de, G.; id_orcid, Kisin, S Srdjan, Varst, PGT Paul van der, With, G Bert de, Kisin, S., Varst, van der, P.G.T.   +6 more
core   +1 more source

Interfaces for Science: Conceptualizing an Interactive Graphical Interface [PDF]

, 2019
This work has been supported by COMPETE: POCI-01-0145-FEDER-007043 and FCT - Fundação para a Ciência e Tecnologia within the Project Scope: (UID/CEC/00319/2013) and the Project IViSSEM: ref: POCI-01-0145-FEDER-28284.
Bruno Azevedo, Ana Alice Baptista, Jorge Oliveira e Sá, Pedro Branco 0001, Rubén Tortosa   +4 more
openaire   +3 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Revealing the structure of the active sites for the electrocatalytic CO2 reduction to CO over Co single atom catalysts using operando XANES and machine learning

Journal of Synchrotron Radiation
Transition-metal nitrogen-doped carbons (TM-N-C) are emerging as a highly promising catalyst class for several important electrocatalytic processes, including the electrocatalytic CO2 reduction reaction (CO2RR).
Andrea Martini, Janis Timoshenko, Martina Rüscher, Dorottya Hursán, Mariana C. O. Monteiro, Eric Liberra, Beatriz Roldan Cuenya   +6 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source