Results 91 to 100 of about 135,248 (292)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Tolkien\u27s surrealistic pillow: Leaf by Niggle [PDF]
, 2018 This article proposes a link between J.R.R. Tolkien’s autobiographical short story Leaf by Niggle and twentieth century Surrealism. Elements of the story which are suggestive of surrealistic fantasy are discussed, alongside its singular origin and role ...
Organ, Michael
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Ant Similes in J.R.R. Tolkien’s The Lord of the Rings – an Analysis of Literary Technologies
FafnirThis article investigates the use of similes in J.R.R. Tolkien’s writing as literary-technological design that partakes in traditional means for narrative meaning-making repurposed for his fantasy in The Lord of the Rings.
Juha-Pekka Alarauhio
doaj
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Między Oryginałem a Przekładem, 2017 Literature and film, since the birth of the latter, have been developing together and influencing one another. Although incomparable on the constructional level, those two arts are similar in nature.
Aleksandra Stodolna
doaj +1 more source
, 2013 Shieldmaiden is a poem that examines J.R.R. Tolkien\u27s Lord of the Rings series from a feminist perspective, focusing on the character of Éowyn and her influence on female readers of Tolkien\u27s ...
Taylor, Allison A.
core
FRODO’S LOYALTY REFLECTED IN PETER JACKSON’S THE LORD OF THE RINGS TRILOGY (2001-2003): AN INDIVIDUAL PSYCHOLOGICAL APPROACH [PDF]
, 2010 The major problem of this study is to know how does Frodo’s loyalty to keep the ring until it is destroyed reflected in The Lord of the Rings. The objectives of the study are: to expose the Frodo Baggins’ loyalty based on the individual psychological ...
HANDAYANI , CATUR SRI
core
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source