Results 111 to 120 of about 5,136 (295)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Our Methodological Challenges and Solutions [PDF]
, 2008 How did audiences across the world respond to the films of The Lord of the Rings? The book presents findings from the largest film audience project ever undertaken, drawing from 25,000 questionnaire responses and a wide array of other materials ...
MATHIJS ERNEST +2 more
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Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Ideology in The Lord of the Rings: a Marxist Analysis [PDF]
A Marxist analysis of The Lord of the Rings reveals two major insights: firstly, Tolkien defends class division, one based on inheritance and, secondly, within the battles and courtly love themes, there is an embedded Catholicism.
Higham, Steve
core
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
The Lord of the Rings Cinematic British fantasy [PDF]
Among the dazzling array of fantasy literary works, the most classic is undoubtedly the "Lord of the Rings" by British author J.R.R. Tolkien. The entire Middle-earth world system and the basic settings of the other-dimensional world he created have laid ...
Rodriguez, Sophie, Johnson, Michael
core +2 more sources
Vegetal Modes of Resistance: Arboreal Eco-Rebellion in The Lord of the Rings
HumanitiesThis article posits that a fictional eco-rebel might be not just a human (child or young adult), but also a plant, revolting against the destruction of its dwelling place. The argument is furthered by way of a literary analysis of arboreal agency in J. R.
Lykke Guanio-Uluru
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
J. R. R. Tolkien’s 'The Lord of the Rings': The Book, the Film, and Genre Criticism [PDF]
, 2008 Contemporary audiences recognize the distinctive bookshop genre of “fantasy literature” that appeared following the publication of J. R. R. Tolkien’s The Lord of the Rings in 1954- 55.
Selling, Kim
core +1 more source