Results 101 to 110 of about 135,248 (292)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

WAYS OF TRANSLATING METAPHORS IN J.R.R.TOLKIEN’S “THE LORD OF THE RINGS”

open access: yesStudia Universitatis Moldaviae: Stiinte Umanistice, 2008
Articolul prezent este dedicat studiului contrastiv al traducerii metaforei de către doi translatori V.Muraviov şi V.Motorina în romanul lui J.R.R.Tolkien “Regele inelelor”.
USM ADMIN
doaj  

Naming, Order and Power: She Unnames Them All of Ursula & Lord of the Rings of Tolkien

open access: yesİstanbul Hukuk Mecmuası
One of the two points that establishes a relationship between law and literature is the legal themes in literary works, and the other is the literary character of law itself.
O. Vahdet İşsevenler
doaj   +1 more source

Білі плями на золотому персні: до питання про композиційну будову та образи роману Дж. Р. Р. Толкієна "Володар перснів" [PDF]

open access: yes, 2012
(UA) Незважаючи на ретельне виписування усіх предметних та пейзажних деталей, майстерно виписаний історичний фон культової книги ХХ століття - трилогії Дж. Р. Р.
Козій, Ольга Борисівна
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Women & Tolkien: Amazons, Valkyries, Feminists, and Slashers [PDF]

open access: yes, 2018
This paper reports on an early pilot project that asks women who self identify as readers or fans of Tolkien\u27s work and/or teachers who have taught Tolkien\u27s work, and/or scholars who have published on Tolkien\u27s work to answer a few open-ended ...
Reid, Robin A., Dr.
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

The universe of the quasi-realia of the novel “The lord of the rings” by J. R. R. Tolkien [PDF]

open access: yes, 2015
В статье рассматривается пространство квазиреалий романа Дж. Р.Р. Толкина «Властелин Колец», исследуются исторические и этимологические корни квазиреалий в нём, а также анализируются классификации квазиреалий романа и предлагается свой вариант ...
Bozhko, E. M., Божко, Е. М.
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

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