Results 121 to 130 of about 3,613,732 (315)

Meaning in Life and Pain: The Differential Effects of Coherence, Purpose, and Mattering on Pain Severity, Frequency, and the Development of Chronic Pain

open access: yesJournal of Pain Research, 2022
Brandon L Boring,1 Joseph Maffly-Kipp,1 Vani A Mathur,1,2 Joshua A Hicks1 1Department of Psychological and Brain Sciences, Texas A&M University, College Station, TX, 77843, USA; 2Institute for Neuroscience, Texas A&M University, College Station, TX ...
Boring BL   +3 more
doaj  

Meaning-of-life orientations and satisfaction with life in elderly people

open access: bronze, 2020
Natalia G. Ermakova   +2 more
openalex   +1 more source

Beauvoir’s ethics, meaning, and competition [PDF]

open access: yes, 2019
This paper discusses Simone de Beauvoir’s views on the meaning of life as presented in The Ethics of Ambiguity. I argue that Beauvoir’s view matches contemporary hybrid views on the meaning of life, incorporating both subjective and objective elements ...
Popa, Elena
core  

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

open access: yesFEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang   +8 more
wiley   +1 more source

His and Hers: Exploring Gender Puzzles and the Meaning of Life Satisfaction [PDF]

open access: yes
Our paper contributes to current debates around work-life balance and the efficiency and wellbeing costs associated with different models of work and childcare (Gregory and Connolly, 2008).
Marina Della Giusta, Uma Kambhampati
core   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

open access: yesFEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang   +9 more
wiley   +1 more source

About the role of orthodox psychotherapy in neurotic disorders treatment (notes orthodox psychologist)

open access: yesКонсультативная психология и психотерапия, 2011
The article examines the causes of unsatisfactory results in neurotic disorders treatment by secular methods of psychotherapy, trying to interpret them in terms of Christian anthropology.
Legostaeva M.V.
doaj  

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

open access: yesFEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Meaning in Life of Terminally Ill Parent with Young Children – A Quantitative Evaluation with SMiLE [PDF]

open access: green, 2021
Henning Cuhls   +4 more
openalex   +1 more source

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