Results 51 to 60 of about 127,549,073 (315)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

A sustainable model for enhancing road quality with recycled plastic bags

Kuwait Journal of Science, 2019
Plastic waste disposal is becoming a serious challenge to all major metropolitan municipalities around the world. If not disposed of properly, the plastic wastes can degrade the environment for several years.
Osman Gulseven, Shaimaa Ashkanani, Sarah Abdullah, Hawraa Ismaeil, Haneen Alkandari, Mariam Baroun   +5 more
doaj  

Impact of environmental, social, governance, and corporate social responsibility factors on firm’s marketing expenses and firm value: A panel study of US companies

Cogent Business & Management, 2022
During recent times of uncertainty, sustainable marketing and sustainable finance became hot research topics attracting both academics and practitioners.
Nermain Al-Issa, Audil Rashid Khaki, Ammar Jreisat, Somar Al-Mohamad, Dina Fahl, Emira Limani   +5 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Exploiting heart rate variability for driver drowsiness detection using wearable sensors and machine learning

Scientific Reports
Driver drowsiness is a critical issue in transportation systems and a leading cause of traffic accidents. Common factors contributing to accidents include intoxicated driving, fatigue, and sleep deprivation.
Zakwan AlArnaout, Chamseddine Zaki, Yehia Kotb, Mouhammad AlAkkoumi, Nour Mostafa   +4 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

3D SPH-FEM MODELLING OF MICRO MILLING OF Ti-6Al-4V

Journal of Advances in Manufacturing Engineering, 2022
Modelling of micro milling process is still one of the most challenging research topics. This paper presents a new 3D SPH-FEM technique used to model micro end milling operation of titanium alloy.
Murat Demiral, Ali Mamedov
doaj  

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Utilizing Dry Electrode Electroencephalography and AI Robotics for Cognitive Stress Monitoring in Video Gaming

Applied System Innovation
This research explores the integration of the Dry Sensor Interface-24 (DSI-24) EEG headset with a ChatGPT-enabled Furhat robot to monitor cognitive stress in video gaming environments.
Aseel A. Alrasheedi, Alyah Z. Alrabeah, Fatemah J. Almuhareb, Noureyah M. Y. Alras, Shaymaa N. Alduaij, Abdullah S. Karar, Sherif Said, Karim Youssef, Samer Al Kork   +8 more
doaj   +1 more source