Results 61 to 70 of about 3,589,221 (367)
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Constraints on mass loss and self-enrichment scenarios for the globular clusters of the Fornax dSph [PDF]
, 2012 Recently, high-dispersion spectroscopy has demonstrated conclusively that four of the five globular clusters (GCs) in the Fornax dwarf spheroidal galaxy are very metal-poor with [Fe/H]
S. Larsen +7 more
semanticscholar +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Spectral changes during dipping in low-mass X-ray binaries due to highly-ionized absorbers [PDF]
, 2005 X-ray observations have revealed that many microquasars and low-mass X-ray binaries (LMXBs) exhibit narrow absorption features identified with resonant absorption from Fe XXV and Fe XXVI and other abundant ions.
M. D. Trigo +11 more
semanticscholar +1 more source
Organic agriculture in the Netherlands [PDF]
, 2009 Dutch organic agriculture has unique characteristics and peculiarities. It is still a relatively small sector compared to conventional agriculture in the Netherlands.
Hommes, M., Sukkel, W.
core +1 more source
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Scandinavian Journal of Work, Environment & Health, 2021 OBJECTIVES: This study aimed to examine the contribution of employer characteristics to continued employment of employees with residual work capacity.
Raun van Ooijen +3 more
doaj +1 more source
The origin of crystalline silicates in the Herbig Be star HD 100546 and in comet Hale-Bopp [PDF]
, 2003 the date of receipt and acceptance should be inserted later Abstract. We have investigated the spatial distribution, and the properties and chemical composition of the dust orbiting HD100546. This system is remarkably different from other isolated Herbig
J. Bouwman +11 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source