Results 71 to 80 of about 128,506,783 (259)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

PAN-00044751 - cingulum buckle of the Osterburken type

open access: yes, 2023
This find is registered at Portable Antiquities of the Netherlands with number PAN ...
Portable Antiquities of the Netherlands, DataCurator
core   +1 more source

The effect of ill health and socioeconomic status on labor force exit and re-employment: a prospective study with ten years follow-up in the Netherlands

open access: yesScandinavian Journal of Work, Environment & Health, 2013
OBJECTIVES: The aim of this study was to investigate the effect of ill health and socioeconomic status on labor force exit due to unemployment, early retirement, disability pension, or becoming economically inactive.
Merel Schuring   +4 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

Youth and politics in the Netherlands 1964

open access: yes, 2007
Political information / political interest / political expectations / war, peace expectations / attitude towards disarmament.
Daudt, H., Lange, H., Universiteit van Amsterdam * Amsterdam, Instituut voor wetenschap der politiek, IWP, Nederlands instituut voor de publieke opinie en het marktonderzoek, NIPO * Amsterdam (primary investigator)
core   +1 more source

PAN-00018752 - supporting-arm brooch of the Lower Rhine type

open access: yes, 2020
This find is registered at Portable Antiquities of the Netherlands with number PAN ...
Portable Antiquities of the Netherlands, DataCurator
core   +1 more source

PAN-00004622 - cingulum buckle of the Oberstimm type

open access: yes, 2021
This find is registered at Portable Antiquities of the Netherlands with number PAN ...
Portable Antiquities of the Netherlands, DataCurator
core   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

open access: yesMolecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh   +11 more
wiley   +1 more source

PAN-00074110 - figurine in the shape of a chicken

open access: yes, 2020
This find is registered at Portable Antiquities of the Netherlands with number PAN ...
Portable Antiquities of the Netherlands, DataCurator
core   +1 more source

PAN-00031806 - cingulum buckle of the Oberstimm type

open access: yes, 2021
This find is registered at Portable Antiquities of the Netherlands with number PAN ...
Portable Antiquities of the Netherlands, DataCurator
core   +1 more source

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