Results 61 to 70 of about 853,680 (253)
Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler +20 more
wiley +1 more source
Should we be Scared of all Salafists in Europe?
Perspectives on Terrorism, 2014 European governments consider the Salafi movement to be primarily a security threat. Yet developments in the Dutch Salafi movement reveal that quietist and political Salafists distance themselves from coercion and violence in the European context and ...
Ineke Roex
doaj
Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett +8 more
wiley +1 more source
Politics and GovernanceRepresentative democracy functions optimally when all citizens can participate, are heard, and feel represented. We know, however, that those interested and satisfied in politics rarely reflect a cross-section of the population.
Floris Vermeulen +3 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown +6 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang +8 more
wiley +1 more source
Stone Aggregations or Reefs? Knowledge Politics Around a Transboundary Seabed Complex
Ocean and SocietyThis study analyses marine governance and knowledge politics of sediments in the Borkum Reef Ground from a historical and German perspective, as well as in the context of litigation against marine gas production from transboundary Dutch and German fields.
Irit Ittner, Anna‐Katharina Hornidge
doaj +1 more source
The Power of Envisioning: Projective design as a tool for embracing radical change
Urban Transcripts, 2021 During the summer of 2019, the National Environmental Vision (De Nationale Omgevingsvisie-NOVI), was published in the Netherlands. For the first time in planning history, the Netherlands got a full-scale vision, not just for infrastructure or land use ...
Aikaterina Myserli, Henk Hartzema
doaj
A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling +16 more
wiley +1 more source