Results 31 to 40 of about 184,928,024 (293)

The reasonableness among the principles of the law-application process

open access: yesТеорія і практика правознавства, 2016
The main requirements for the process of law application are described in the article. The author analyzes the principle of reasonableness in the system of law-enforcement. The importance of reasonableness in the common law countries is discussed.
К. О. Мандрикова
doaj   +1 more source

Reframing the Proportionality Principle [PDF]

open access: yes, 2018
Proportionality functions as one of the most important legal constraints applicable to the conduct of hostilities. In that context, this short essay discusses the commonly encountered misapplications of Cicero\u27s classic sentiment that salus populwe ...
Newton, Michael A.
core   +4 more sources

Impact of Initial Treatment Setting on Survival in Relapsed Pediatric and AYA Bone Sarcomas: A Secondary Analysis of a Prospective Clinical Trial

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Outcomes in relapsed or refractory pediatric and AYA bone sarcomas remain poor, and the impact of early referral to specialized sarcoma centers on survival is unclear. Early centralization of care may improve local and systemic treatment quality, but evidence in this population is limited.
Justyna Antoniuk‐Majchrzak   +9 more
wiley   +1 more source

PRINCIPLE OF PROPORTIONALITY IN ADMINISTRATIVE ADJUDICATION [PDF]

open access: yes, 2016
Svrha je ovoga rada istražiti institut razmjernosti te njegov utjecaj na hrvatsko upravno i upravnosudsko odlučivanje. U radu se najprije utvrđuje značenje i sadržaj načela razmjernosti, kao općeg pravnoga načela.
Đerđa, Dario
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

The Principle of Proportionality: Critique of Theoretical Standpoints and Its Relevance [PDF]

open access: yes, 2021
99 The Principle of Proportionality: Critique of Theoretical Standpoints and Its Relevance Abstract: A decision concerning a fundamental rights conflict needs to respect the principle of proportionality in order to be compatible with a constitutional ...
Koref, Tomáš
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The burgeoning constitutional requirement of rationality and separation of powers has rationality review gone too far? [PDF]

open access: yes, 2013
This thesis presents an analysis of three recent judgments of our apex courts which collectively illustrate a maximising of the 'minimum threshold requirement' of rationality through the seemingly inexhaustible constitutional principle of legality.
Kohn, Lauren Manon
core   +1 more source

EU Courts’ review of decisions imposing fines in EU state aids cases

open access: yesActa Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2013
The aim of this article is to provide a comprehensive view on the application of the principle of proportionality in the Commission’s decisions imposing fines in the area of state aids as well as the EU courts exercise of the jurisdiction over these ...
Jana Mikušová
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

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