Results 51 to 60 of about 881,359 (300)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Distributed Adaptive Affine Formation Control for Heterogeneous Linear Networked Systems

IEEE Access, 2019
This paper addresses the distributed adaptive affine formation protocol design problem for the heterogeneous leader-follower-type linear networked systems, in which the interaction graph is directed.
Yang Xu, Delin Luo, Yancheng You, Haibin Duan   +3 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Two-stage index computation for bandits with switching penalties I : switching costs [PDF]

, 2007
This paper addresses the multi-armed bandit problem with switching costs. Asawa and Teneketzis (1996) introduced an index that partly characterizes optimal policies, attaching to each bandit state a "continuation index" (its Gittins index) and a ...
Niño Mora, José
core   +4 more sources

Stochastic User Equilibrium and Value-of-time Analysis with Reference-dependent Route Choice

European Journal of Transport and Infrastructure Research, 2011
Reference-dependent theory of riskless choice assumes that carriers of utility are gains and losses relative to a reference point and that individuals are loss averse, i.e. losses are valued more highly than gains.
Paolo Delle Site, Francesco Filippi
doaj   +1 more source

Stream temperature modeling and fiber optic temperature sensing to characterize groundwater discharge [PDF]

, 2019
The Ngongotaha Stream was used as a case study to assess the applicability of fiber optic distributed temperature sensing (FODTS) to identify the location of springs and quantify their discharge.
Moridnejad, Maryam
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Event-Based H∞ filter design for a class of nonlinear time-varying systems with fading channels and multiplicative noises [PDF]

, 2015
In this paper, a general event-triggered framework is developed to deal with the finite-horizon H∞ filtering problem for discrete time-varying systems with fading channels, randomly occurring nonlinearities and multiplicative noises.
Ding, SX, Dong, H, Gao, H, Wang, Z
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

The Improving Efficiency Measurement and Discriminating Power in the DEA Models with Presentation of a new Model of CSW [PDF]

بهبود مدیریت, 2013
Data Envelopment Analysis (DEA) is a wide range of mathematical models for measuring the relative efficiencies of a set of Decision Making Units (DMUS) that use similar inputs to produce similar outputs.
Adel Azar, Mohammad Zareei Mohmood Abadi
doaj