Results 61 to 70 of about 881,359 (300)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Multi-Level Multimodal Common Semantic Space for Image-Phrase Grounding [PDF]
Computer Vision and Pattern Recognition, 2018 We address the problem of phrase grounding by learning a multi-level common semantic space shared by the textual and visual modalities. We exploit multiple levels of feature maps of a Deep Convolutional Neural Network, as well as contextualized word and ...
Hassan Akbari +5 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
A Close-to-linear Topic Detection Algorithm using Relative Entropy based Relevance Model and Inverted Indices Retrieval [PDF]
International Journal of Computational Intelligence Systems, 2012 Although timely access to information is becoming increasingly important and gaining such access is no longer a problem, the capacity for humans to assimilate such huge amounts of information is limited.
Steve Kansheng Shi, Lemin Li
doaj +1 more source
Likelihood-informed dimension reduction for nonlinear inverse problems [PDF]
, 2014 The intrinsic dimensionality of an inverse problem is affected by prior information, the accuracy and number of observations, and the smoothing properties of the forward operator.
Cui, Tiangang +4 more
core +2 more sources
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Multiple sclerosis and pregnancy- treatment considerations
Journal of Pre-Clinical and Clinical Research, 2020 Multiple sclerosis is a chronic inflammatory disease which, due to the destruction of the fibres of the central nervous system in the process of demyelination, leads to numerous neurological symptoms and progressive disability. The disease is autoimmune,
Maciej Piotr Kamieniak +6 more
doaj +1 more source
Learning to deal with risk: what does reinforcement learning tell us about risk attitudes? [PDF]
People are generally reluctant to accept risk. In particular, people overvalue sure gains, relative to outcomes which are merely probable. At the same time, people are also more willing to accept bets when payoffs involve losses rather than gains.
Albert Burgos
core
Analysis and Performance Evaluation of the ZEM/ZEV Guidance and its Sliding Robustification for Autonomous Rendezvous in Relative Motion [PDF]
, 2016 Devising closed-loop guidance algorithms for autonomous relative motion is an important problem within the field of orbital dynamics. In this paper, we study the guided relative motion of two spacecraft for which one of them is executing an autonomous ...
Casotto, Stefano +4 more
core