Results 101 to 110 of about 128,071,639 (264)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

STUDY AND DIAGNOSIS OF THE CURRENT CONDITION OF THE STATUE OF AMENHOTEP III IN THE GRAND EGYPTIAN MUSEUM

Journal of the General Union of Arab Archaeologists
This research aims to study and diagnose the current condition of the statue of Amenhotep III in the Grand Egyptian Museum, using modern techniques to identify its components and manifestations of deterioration to determine the nature of the statue’s ...
Sameh Ahmed Rohayem, SHAABAN MOHAMED MAHMOUD ABDELAAL   +1 more
doaj   +1 more source

Multi‐Metric Monitoring: Comparing Occupancy and Abundance Based Metric Sensitivity for Detecting Threatened Species Responses to Environmental Change

Global Change Biology Communications
Detecting how threatened species populations respond to accelerating environmental change requires monitoring frameworks that are sensitive and precise.
Tim S. Jessop, Graeme R. Gillespie, Ben Hope, Elliot Webb, Matt Clements, Nicole Gallahar, Mez Kocyigit, Mark Le Pla   +7 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Bukhara Old City Restoration

ma
Uzbek Institute of Restoration
core   +2 more sources

Integrating Aging-Friendly Strategies into Smart City Construction: Managing Vulnerability in Rural Mountainous Areas

Buildings
The vulnerability of older adults in rural mountainous regions presents a critical challenge for sustainable development, particularly in the context of smart city and digital town construction.
Kexin Chen, Yangyang Lei, Qian Liu, Jing’an Shao, Xinjun Yang   +4 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The Law of Ecosystem Restoration for Community Conservation Groups [PDF]

, 2008
Across New Zealand communities have identified the need to restore and rehabilitate damaged ecosystems in their locality. However, community conservation groups (CCGs) often face significant obstacles when undertaking activities to restore and ...
Ewing, Kellie Joy
core  

The Restoration Of Tropical Seed Dispersal Networks

, 2016
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Human activities have led to the loss of habitats and biodiversity in the Atlantic Rain Forest in Brazil.
Ricardo R., Rafael; Memmott, Daniel; Furtado, Marco A.; Rodrigues, Jane; Pizo, Fernanda Ribeiro; Montoya, da Silva   +6 more
core   +1 more source