Results 51 to 60 of about 179,934,146 (216)

RESULTS OF UNIFIED SYSTEM OF INDIVIDUAL DOSE CONTROL FUNCTIONING DURING 2008

Радиационная гигиена, 2016
.
openaire   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

An on-line training radial basis function neural network for optimum operation of the UPFC [PDF]

, 2010
The concept of Flexible A.C. Transmission Systems (FACTS) technology was developed to enhance the performance of electric power networks (both in steady-state and transient-state) and to make better utilization of existing power transmission facilities ...
Farrag, M. E. A., M. E. A. Farrag, Ghanim Putrus, Putrus, G., Farrag, Mohamed, Putrus, Ghanim, Farrag, Mohamed; id_orcid   +6 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Operation and control of island systems-the Crete case

, 2000
International audienceIn this paper, an advanced control system for the optimal operation and management of isolated power systems with increased renewable power integration is presented.
Pecas Lopes, J.A., Papadias, B, A. Gigantidou, Halliday, J., N. Hatziargyriou, Gigantidou, A., E. Nogaret, Matos, M.A., P. Dokopoulos, A. Bakirtzis, Matos, M, Halliday, J, Lopes, J, Bakirtzis, A, Papadias, B., Dokopoulos, P., J. Stefanakis, Dokopoulos, P, B. Papadias, G. Contaxis, Androutsos, A., Bakirtzis, A., G. Dutton, J.A. Pecas Lopes, Stefanakis, J., Contaxis, G, Papadopoulos, M, G. Kariniotakis, Contaxis, G., Papadopoulos, M., Nogaret, E, Stefanakis, J, M.A. Matos, Dutton, G, M. Papadopoulos, Hatziargyriou, N., Gigantidou, A, Androutsos, A, J. Halliday, Kariniotakis, Georges, A. Androutsos, Nogaret, E., Dutton, G., Kariniotakis, G, Hatziargyriou, N   +44 more
core   +1 more source