Results 71 to 80 of about 7,296 (233)
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Sites of action. An investigation of performance painting and spectatorship
, 2013 This practice-based research sets out to explore modes of address and spectatorship in relation to contemporary painting. Taking as its point of departure Michael Fried’s Absorption and Theatricality: Painting and Beholder in the Age of Diderot (1980), I
Hawkins, Kate
core +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
НеофилологияINTRODUCTION. B. Brecht’s theory of epic theater to some extent influenced the formation and development of Vladimir Vysotsky’s poetic system. The aim of the study is to identify and analyze the typological similarities in the fundamental details of the ...
L. E. Khvorova, P. A. Kokhanov
doaj +1 more source
There is no way you can frame it. Ideias de Teatro e Cinema a partir de Michael Fried
MatLit, 2014 I analyze the concepts of theatre and film in Michael Fried's "Art and Objecthood" (1967), in order to argue for a cinematic theatricality immune to the anti-theatrical prejudice often found in works about the intersection of these two art forms.
Francisco Frazão
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Tipologii feminine în dramaturgia lui Romulus Guga [PDF]
Revista de Istorie și Teorie Literară, 2014 The analytical approach, focusing on the plays of Romulus Guga, aims to make a constructive distinction between the male and female discourse, not mainly for gender-specific reasons, but in order to identify a dramatic vision in which the female ...
Cristina Rotaru
doaj
Staging enmity: reading populist productions of shame with Jelinek's On the Royal Road. [PDF]
Open Res Eur, 2023 Prade-Weiss J.
europepmc +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source