Results 221 to 230 of about 5,049 (275)
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Dearomative Access to (−)-Thebaine and Derivatives
Organic Letters, 2023A synthesis of the natural product thebaine is reported in eight steps from commercially available starting materials, hinging on the dearomatization and coupling of simple aromatic starting materials. This provides divergent access to two unnatural opioid derivatives and is aimed at the long-term development of synthetic opioid analogs of the ...
Zachary A. Tolchin +3 more
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Structural insights into thebaine synthase 2 catalysis
Biochemical and Biophysical Research Communications, 2020Thebaine synthase 2 (THS2) that can transform (7S)-salutaridinol 7-O-acetate to thebaine catalyzes the final step of thebaine biosynthesis in Papaver somniferum. Here, the crystal structures of THS2 and its complex with thebaine are reported, revealing the interaction network in the substrate-binding pocket.
Chun-Chi Chen +13 more
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A cluster of acute thebaine poisonings from non-food grade poppy seeds in the Australian food supply
Clinical toxicology, 2023Introduction Poppy seed tea is used for its opioid effects and contains multiple opium alkaloids, including morphine, codeine, papaverine, and thebaine.
K. Isoardi +12 more
semanticscholar +1 more source
Toxicokinetics of thebaine in those consuming non-food grade poppy seeds as a tea
Clinical toxicology, 2023Introduction Thebaine is an alkaloid in poppy seeds that is neurotoxic to animals. Data on its clinical effects and toxicokinetics in people are minimal.
Rowena Penafiel +7 more
semanticscholar +1 more source
Chemical Communications, 2023
A whole cell Escherichia coli biotransformation platform converting thebaine to oripavine and codeine to morphine was demonstrated with industrially applicable yields (∼1.2 × 10-2 g L-1 h-1 or ∼1.2 × 10-1 g L-1 h-1), improving >13 400-fold upon morphine ...
Garrick W K Spencer +3 more
semanticscholar +1 more source
A whole cell Escherichia coli biotransformation platform converting thebaine to oripavine and codeine to morphine was demonstrated with industrially applicable yields (∼1.2 × 10-2 g L-1 h-1 or ∼1.2 × 10-1 g L-1 h-1), improving >13 400-fold upon morphine ...
Garrick W K Spencer +3 more
semanticscholar +1 more source
A Seven-Step Total Synthesis of (–)-Thebaine
Synthesis, 2022The morphinan alkaloid (–)-thebaine (1) is an industrially important chemical intermediate deployed in the semi-synthesis of various opioid medicines.
Shen Tan +4 more
semanticscholar +1 more source
Drug Testing and Analysis, 2022
Laboratories are challenged to distinguish whether a positive urine morphine result is due to heroin use or possible poppy seed consumption. Thebaine is an opium alkaloid that has been shown to be present in the urine of individuals who have consumed ...
Stephanie Marina Bollini +2 more
semanticscholar +1 more source
Laboratories are challenged to distinguish whether a positive urine morphine result is due to heroin use or possible poppy seed consumption. Thebaine is an opium alkaloid that has been shown to be present in the urine of individuals who have consumed ...
Stephanie Marina Bollini +2 more
semanticscholar +1 more source
ChemInform Abstract: CONVERSION OF THEBAINE TO CODEINE [PDF]
Chemischer Informationsdienst, 1976 AbstractThebain (II) wird mit Natrium‐tert.‐butylmercaptid zu dem Substitutionsprodukt (I) und Oripavin umgesetzt.
Henry Rapoport, Randy B. Barber
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