Results 41 to 50 of about 17,048 (257)

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Developing interactive multimedia on the thematic-integrative learning for Grade IV students under the sub-theme my food is health and nutritious

open access: yesJurnal Prima Edukasia, 2017
This study aimed at generative a proper and effective Adobe Flash Interactive Multimedia for Grade IB Students under the sub-theme “My Food is Healthy and Nutritious” in SD Negeri Glagah Yogyakarta.
Tri Yuliansyah Bintaro
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

open access: yesFEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis   +2 more
wiley   +1 more source

The Implication of Authentic Assessment in Thematic Integrated Learning Process at Lower Level Elementary School [PDF]

open access: yes, 2018
The assessment done focused on authentic assessment which is sought to assess the students' competence in terms of attitude, knowledge and skill. This research is classified into descriptive study. This research applied concurrent embedded models in which qualitative and quantitative models were applied disproportionately.
null Taufina, null Chandra
openaire   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

PEMBELAJARAN TEMATIK-INTEGRATIF DI SD/MI DALAM KURIKULUM 2013

open access: yesINSANIA: Jurnal Pemikiran Alternatif Kependidikan, 2015
This paper is intended to describe the concept and implementation of thematic-integrated learning in SD/MI. Integrated thematic approach is a learning approach that integrates the various competencies of the various subjects in various tema.
Imam Nur Hakim
doaj   +3 more sources

The multifaceted roles of lysosomes in cancer

open access: yesMolecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

PENGEMBANGAN PERANGKAT PEMBELAJARAN TEMATIK-INTEGRATIF BERBASIS SASTRA BAGI SISWA KELAS V SEKOLAH DASAR

open access: yesJurnal Prima Edukasia, 2016
Penelitian ini bertujuan untuk: (1) menghasilkan perangkat pembelajaran tematik integratif berbasis sastra yang layak bagi siswa kelas V SD, (2) mengetahui efektivitas perangkat pembelajaran tematik integratif berbasis sastra bagi siswa kelas V SD ...
Nurul Mu’minin MZ, Suhardi Suhardi
doaj   +1 more source

Evaluation of Thematic Integrative Learning Programs in Elementary School YPS Pertamina Prabumulih

open access: yesInternational Journal for Educational and Vocational Studies, 2020
The aims of this research is to evaluate the integrative thematic learning : 1). The context component is the environment conditions that support learning, 2). The input component is the school facilities and human resources, 3). The process component is the   process of planning and implementing of integrative thematic learning, and 4).
Khaerul Budhy Nagara   +2 more
openaire   +1 more source

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